PMID: 9553804Apr 29, 1998Paper

The diagnostic utility of inhibin staining in ovarian neoplasms

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
T J PelkeyM H Stoler

Abstract

Previous immunohistologic studies have suggested that the antibody to the alpha subunit of inhibin is a sensitive marker of sex cord-stromal differentiation. However, detection has also been reported within both ovarian epithelial and germ cell tumors. To further study the normal tissue distribution of inhibin and the utility of its detection for the differential diagnosis of ovarian sex cord-stromal neoplasms, normal tissues and 225 lesions including sex cord-stromal lesions, ovarian epithelial and stromal cancers, ovarian and testicular germ cell tumors, metastases to the ovary, and non-ovarian cancers were analyzed using semi-automated immunohistochemistry. In normal tissues, immunostaining was found in cell subsets of the ovary, testis, adrenal gland, placenta, and kidney. All sex cord-stromal tumors were inhibin-positive and 37 of 50 (74%) cases exhibited at least moderate to strong immunostaining. Two cases originally diagnosed as adult granulosa cell tumors that were inhibin-negative were reassessed; diagnoses of endometrioid stromal sarcoma and endometrioid carcinoma with sertoliform features were rendered. In other primary or metastatic ovarian lesions or metastases to the ovary, weak to moderate immunostaining was fou...Continue Reading

Citations

Jul 14, 2001·Molecular and Cellular Endocrinology·H G BurgerD M Robertson
Jan 28, 1999·Molecular and Cellular Endocrinology·N A RahmanI T Huhtaniemi
Jan 6, 1999·Reproductive Toxicology·A M MahmoudC E Depuydt
Jun 16, 1999·Current Opinion in Obstetrics & Gynecology·F PetragliaF M Reis
Feb 24, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W G McCluggage
Oct 18, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Q J CaoM Li
Oct 18, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·F KommossH Müntefering
Mar 22, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Michael T DeaversElvio G Silva
Sep 11, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Davis X YaoRebecca N Baergen
Feb 8, 2007·The American Journal of Dermatopathology·Briana C Gleason, Alessandra F Nascimento
Apr 25, 2006·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W Glenn McCluggage
Jun 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W Glenn McCluggageHilary A McBride
Jun 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Sharon X LiangCarmen Tornos
Apr 17, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Iclal Gurses, Bernd W Scheithauer
Aug 28, 2007·The American Journal of Surgical Pathology·Chengquan ZhaoRussell Vang
Aug 30, 2008·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Chengquan ZhaoRussell Vang
Jul 13, 2000·Journal of Clinical Pathology·W G McCluggage
Dec 28, 2011·Cancer Genetics·Katherine B GeiersbachJoshua D Schiffman
Nov 29, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Caner OzbeySeyda Karaveli
Sep 29, 2004·Molecular and Cellular Endocrinology·David M RobertsonDavid Healy
Sep 29, 2004·Cytokine & Growth Factor Reviews·Emma M A BallGail P Risbridger
Mar 4, 2006·Seminars in Diagnostic Pathology·W Glenn McCluggage, Robert H Young
Feb 13, 2003·Clinical Endocrinology·Stephen TongHenry G Burger
Sep 13, 2011·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Barbara BancoValeria Grieco
Jul 5, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Elena RiccardiMario Finazzi
Mar 21, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Aisling LongworthLynn Hirschowitz
Aug 25, 2007·Advances in Anatomic Pathology·Julie A Irving, W Glenn McCluggage
May 2, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ramon H M DykgraafMaria E L van der Burg
Jan 15, 2002·The Journal of Clinical Endocrinology and Metabolism·Catherine S ChoongHenry G Burger
Dec 12, 2001·Endocrine Reviews·G P RisbridgerD M Robertson
Jan 13, 2005·The American Journal of Surgical Pathology·Esther OlivaRobert H Young
Apr 16, 2019·The American Journal of Surgical Pathology·Anthony N KarnezisFriedrich Kommoss
Mar 15, 2002·Applied Immunohistochemistry & Molecular Morphology : AIMM·Merce JordaMehrdad Nadji
Jun 24, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Marie-Laure PersechiniPhilippe Caron
Mar 16, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Hanan Mohammed Abd ElmoneimHanan Ali
Nov 25, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Meike KörnerJean Claude Reubi
Jun 7, 2007·Archives of Pathology & Laboratory Medicine·Anil Misir, Monalisa Sur

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
W G McCluggage
International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
M A RiopelM E Sherman
International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Q J CaoM Li
International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
M ShimizuS Fujii
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Michael T DeaversElvio G Silva
© 2022 Meta ULC. All rights reserved