Abstract
In this study, we investigated the diagnostic value of human epididymis protein 4 (HE4) in acute and chronic renal dysfunction and analyzed the correlation between HE4 levels and the results of routine renal function tests. We aimed to provide evidence to establish HE4 as a novel biomarker of renal injury and its appropriate application as a marker of ovarian cancer. We collected 259 serum samples from hospitalized patients with different causes of renal damage. HE4 serum levels were detected by chemiluminescence and the levels of serum creatinine, urea, and cystatin C were tested by conventional clinical chemical methods. The levels of HE4 were highest in the acute kidney injury groups and chronic kidney disease groups, although other groups were also significantly higher than the control group. HE4 and creatinine, urea, and cystatin C had a positive linear correlation. In contrast, HE4 and estimated glomerular filtration rate (eGFR) had a negative linear correlation, with a correlation coefficient of - 0.674 (P < 0.01). Area under the receiver-operating characteristic curve analysis showed that HE4 has higher diagnostic value compared with creatinine, urea, and cystatin C in both acute and chronic renal injury patients; howev...Continue Reading
References
Nov 26, 1999·Gene·M SchummerL Hood
Apr 23, 2002·Kidney International·Chi-Yuan HsuGary C Curhan
Feb 9, 2012·Clinical Chemistry·Michael A Ferguson, Sushrut S Waikar
Jun 13, 2012·Annals of Clinical Biochemistry·Béla NagyJános Kappelmayer
Nov 10, 2012·PloS One·Nirmal ChhikaraSavita Yadav
Jan 29, 2013·Nature Medicine·Valerie S LeBleuRaghu Kalluri
Feb 12, 2013·Critical Care : the Official Journal of the Critical Care Forum·John A KellumUNKNOWN KDIGO AKI Guideline Work Group
Apr 16, 2013·American Journal of Obstetrics and Gynecology·Sami K SaarelainenJohanna U Mäenpää
Jun 5, 2013·Annals of Internal Medicine·Paul E Stevens, Adeera Levin
Aug 16, 2013·Oncology Letters·Zhijun YangLi Li
Aug 27, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jonathan A Lindquist, Peter R Mertens
Sep 21, 2013·BMC Cancer·Denise da Rocha PittaSophie Derchain
Oct 11, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Salvatore GizzoMario Plebani
Mar 14, 2014·JACC. Heart Failure·Rudolf A de BoerHerman H W Silljé
Oct 30, 2015·Journal of Endocrinological Investigation·Mariadelina SimeoniGiorgio Fuiano
May 26, 2016·Journal of Cardiac Failure·Arnold PiekHerman H W Silljé
Jun 16, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Laisheng LiMin Liu
Sep 3, 2016·Oncotarget·Jianxin WanLaisheng Li
Citations
Jan 24, 2019·Journal of Ovarian Research·Ying Ying SuYe Fei Zhu
Dec 10, 2019·BioMed Research International·Miaomiao ZhangZaixing Yang
Sep 25, 2019·International Journal of Molecular Sciences·Soichiro TajimaSatohiro Masuda
May 29, 2021·Clinical and Translational Medicine·Donglin SunXiaoren Zhang