The diagnostic value of two commercially available human cTnI assays in goat kids with myocarditis

Veterinary Clinical Pathology
Tolga KarapinarHakan Isidan

Abstract

Cardiac troponin I (cTnI) is a peripheral blood marker for myocardial damage. Because of the unavailability of goat-specific cTnI assays human cTnI assays may be validated for detection of myocarditis in goat kids. The purpose of the study was to evaluate 2 commercially available human cTnI assays in goat kids with myocardial damage, and to determine the cTnI expression in cardiac muscle. Plasma cTnI concentrations were measured in healthy goat kids (n = 7) and goat kids with myocardial damage (n = 8) using the Beckman Coulter Access Accu TnI and the Biomérieux Vidas Ultra. The results were correlated with gross necropsy and histopathologic findings, and cTnI immunhistochemistry in cardiac tissue. Macro- and microscopic findings confirmed myocardial damage in the myocarditis group. Mean plasma cTnI concentration was significantly higher in the myocarditis group than in the healthy control group (104.82 vs 0.02 ng/mL). The overall mean plasma cTnI concentration measured by Biomérieux Vidas Ultra (61.75 ng/mL, 95% CI: 19.55-103.95) was comparable to the mean measured by Beckman Coulter Access Accu TnI (50.08 ng/mL, 95% CI: 24.11-76.06), and cTnI concentrations measured by these assays were highly correlated (r = .977) with a -6.2...Continue Reading

References

Jun 1, 1981·American Journal of Clinical Pathology·S M HsuH Fanger
Aug 15, 1998·American Journal of Clinical Pathology·V RicchiutiF S Apple
Jul 26, 2000·Journal of the American Veterinary Medical Association·C J CornelisseF J Derksen
Aug 29, 2001·Pathology·D Naidoo, UNKNOWN Board of Education of the Royal College of Pathologists of Australasia
May 16, 2002·The Veterinary Clinics of North America. Small Animal Practice·Sharon L Welch
Sep 10, 2002·The Journal of Emergency Medicine·John Sarko, Charles V Pollack
Aug 30, 2005·Clinical Biochemistry·Michael WeberChristian Hamm
Sep 13, 2006·Veterinary Clinical Pathology·Asger Lundorff Jensen, Mads Kjelgaard-Hansen
Jul 4, 2007·Heart, Lung & Circulation·Alan McNeil
Jun 28, 2008·Annals of Clinical Biochemistry·David C Gaze, Paul O Collinson
Feb 5, 2009·Journal of Veterinary Internal Medicine·A VargaD Michael Rings
Aug 7, 2009·Journal of Veterinary Internal Medicine·A VargaD M Rings
Oct 4, 2011·Clinical Chemistry·Fred S AppleUNKNOWN IFCC Task Force on Clinical Applications of Cardiac Biomarkers
Oct 28, 2011·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Keith A BlassThomas J Divers
Jun 13, 2012·Journal of Veterinary Internal Medicine·K SuzukiJ Lakritz
Jul 4, 2012·Veterinary Clinical Pathology·Tolga KarapinarMurat Dabak
May 31, 2013·American Journal of Veterinary Research·Brandon C FraserTom Overbay

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Related Papers

Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology
Joann SlackVirginia Reef
Journal of the American Veterinary Medical Association
Leslie C SharkeyRebecca L Hegstad-Davies
© 2022 Meta ULC. All rights reserved