The Diagnostic Value of Urine Lipoarabinomannan (LAM) Antigen in Childhood Tuberculosis

Journal of Clinical and Diagnostic Research : JCDR
Agustin IskandarMas Slamet Chandrakusuma

Abstract

Diagnosis of Tuberculosis (TB) in children is difficult because the clinical presentation is not specific, the chest X-ray interpretation has low accuracy and sputum sample is difficult to obtain. Antigen detection test such as rapid urine LAM is a non-invasive alternative for diagnosing TB . Lipoarabinomannan (LAM) is the main component of M.tuberculosis cell wall. To determine the diagnostic value of urinary LAM antigen for diagnosis of childhood TB. In the present cross-sectional study, subjects were included using consecutive sampling method. All the children aged 0-14 years Suspected of pulmonary or extra pulmonary TB suffering from cough more than two weeks, fever without clear aetiology, loss of body weight or poor weight gain, fatigue, malaise, chronic lymph node enlargement, spine angulation, joint swelling and had history of contact with positive sputum smear adult TB patient were enrolled in the study. Pulmonary and extra pulmonary diagnosis was based on clinical presentation, Tuberculin Skin Test (TST), chest X-ray, Acid Fast Bacillus (AFB) staining and or sputum culture. Urinary LAM level was measured by using Enzyme-Linked Immunosorbent Assay (ELISA). Cut off value and Area Under the Curve (AUC) were determined us...Continue Reading

Citations

Sep 14, 2018·PloS One·Toyin Omotayo TogunMadhukar Pai
Sep 27, 2020·International Journal of Molecular Sciences·Shailja JakharHarshini Mukundan
Oct 22, 2019·The Cochrane Database of Systematic Reviews·Stephanie BjerrumMaunank Shah
Mar 18, 2021·Infection and Drug Resistance·Luis Horacio Gutiérrez-GonzálezYolanda Gonzalez
May 1, 2021·Journal of Clinical Medicine·Patricia Comella-Del-BarrioJosé Domínguez

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