The diagnostic values of UCH-L1 in traumatic brain injury: A meta-analysis

Brain Injury : [BI]
Shima ShahjoueiKevin K W Wang

Abstract

Traumatic brain injury (TBI) is a major health concern. The purpose of this study is to identify the diagnostic accuracy of ubiquitin C-terminal hydrolase-L1 (UCH-L1)-a protein biomarker-in comparison with CT-scan findings post-TBI. Accordingly, we conducted a systematic review of eligible studies and assessed the risk of bias according to the QUADAS-2 checklist. A total of 13 reports from 10 original studies were included. Based on our analysis, serum UCH-L1 has a high accuracy in predicting CT findings in mild to moderate TBI. Based on the QUADAS-2 checklist, this result has a high risk of bias affecting its applicability. The plasma level of UCH-L1 has moderate accuracy in predicting CT findings when assessed in all GCS levels. This result has a low risk of bias and low concerns regarding applicability. Pooled analysis suggests that the plasma/serum UCH-L1 level has high accuracy in predicting CT findings in a wide range of GCS in patients with TBI. This result has a high risk of bias and high concern about its applicability. The heterogeneity in approaching TBI biomarker interferes with drawing a definitive conclusion. Therefore, although UCH-L1 is a promising blood-based diagnostic biomarker for TBI, but due to differences...Continue Reading

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Citations

Apr 11, 2019·Journal of Neurotrauma·Paymon Garakani RezaiiMax Wintermark
Aug 28, 2020·Frontiers in Neuroscience·Aurélie LedreuxAnn-Charlotte Granholm
Feb 8, 2019·Frontiers in Neuroscience·Maliheh MohamadpourPeter J Bergold
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Jul 7, 2019·The Journal of Surgical Research·Mackenzie C MorrisMichael D Goodman
Nov 3, 2020·Clinical and Translational Medicine·Steven D HicksFrank Middleton

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