PMID: 9188082May 12, 1997Paper

The diastolic decay constant in spontaneously hypertensive rats versus WKY rats as an indicator for vasomotor control

Journal of the Autonomic Nervous System
S EyalS Akselrod

Abstract

This research uses the diastolic decay constant (tau) to investigate the short term mechanism responsible for vasomotor control, mainly the alpha-sympathetic control system. Previous studies have shown that vasomotor control is altered in spontaneously hypertensive rats (SHR) preceding the phase of overt hypertension. The diastolic decay, according to the two element Windkessel model, displays an exponential shape with a decay constant, tau, depending on both the vascular resistance and the compliance. In our experiments, we used tau to characterize vasomotor activity and its control in the normotensive rats as well as in the spontaneously hypertensive rats (SHR) prone to hypertension. The beat to beat value of tau was evaluated from a continuous arterial blood pressure (ABP) signal, measured in the tail artery of the conscious, unrestrained rat. Four months old prehypertensive SHR were compared to their age matched normotensive controls (WKY). To study vasomotor regulation, we computed gains and delay times by investigating the compensatory response in tau to changes in mean ABP (MBP). These parameters are expected in the short term to be neurally controlled by the sympathetic system, mainly alpha-sympathetic. Our set of exper...Continue Reading

References

Jul 30, 1976·Pflügers Archiv : European journal of physiology·R BusseT Pashch
Aug 1, 1992·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·M F O'Rourke, H R Brunner
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Mar 1, 1963·Japanese Circulation Journal·K OKAMOTO, K AOKI

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Citations

Jul 28, 2001·Autonomic Neuroscience : Basic & Clinical·S EyalS Akselrod

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