The dichotomous nature of dose enhancement by gold nanoparticle aggregates in radiotherapy

Nanomedicine
Sherif M GadoueErno Sajo

Abstract

In nanoparticle-aided radiotherapy, the computational paradigm has been that inside the cell, nanoparticles are distributed sparsely and solitarily. However, experiments reveal significant cluster formation, which affects radiosensitization and must be considered in clinical treatment planning. We characterize the impact of gold nanoparticle agglomeration on the predicted radiation dose enhancement as function of size, geometry, morphology and incident beam energy. Next-generation coupled electron-photon deterministic computations were performed using subnanometric unstructured spatial mesh. Unlike single nanoparticles, agglomerates develop two types of dose enhancement, smooth peripheral distributions and isolated hotspots, which depend on the cluster size and geometry in opposite ways. The peripheral dose enhancement may have less importance than the hotspots, which can have greater contribution to cell kill via radical creation. Hence, aggregate formation may be beneficial in nanoparticle-aided radiotherapy.

References

Apr 13, 2006·Nano Letters·B Devika ChithraniWarren C W Chan
Jun 2, 2007·Journal of Colloid and Interface Science·Soumen BasuTarasankar Pal
Sep 15, 2007·The Journal of Physical Chemistry. B·Joshua D CarterTing Guo
Jul 12, 2011·ACS Nano·Alyssa J PasqualeLuca Dal Negro
Sep 16, 2011·Environmental Science & Technology·Haoyang Haven LiuYoram Cohen
Sep 20, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Stephen J McMahonFred J Currell
Feb 8, 2013·Medical Physics·Piotr ZygmanskiErno Sajo
Oct 31, 2013·Physics in Medicine and Biology·Piotr ZygmanskiErno Sajo
Jan 1, 2010·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Asghar Mesbahi
Jul 1, 2014·Nanomedicine·Wilfred NgwaG Mike Makrigiorgos
Jul 2, 2014·Radiation Oncology·Julie MarillAgnes Pottier
Dec 10, 2015·Nanoscale·Stephen J McMahonKevin M Prise
Mar 13, 2017·Nanomedicine : Nanotechnology, Biology, and Medicine·Sherif M GadoueErno Sajo
Oct 17, 2017·Nature Communications·Qiaofeng YaoJianping Xie

❮ Previous
Next ❯

Citations

Dec 22, 2020·Advanced Science·Sandhya ClementEwa M Goldys
Mar 27, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·H RabusH Nettelbeck

❮ Previous
Next ❯

Software Mentioned

SCEPTRE
CEPXS
DERhot
DERper

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics
R P DattaJ E Morel
Nanomedicine : Nanotechnology, Biology, and Medicine
Sherif M GadoueErno Sajo
© 2022 Meta ULC. All rights reserved