The Dietary Antioxidant Piceatannol Inhibits Adipogenesis of Human Adipose Mesenchymal Stem Cells and Limits Glucose Transport and Lipogenic Activities in Adipocytes

International Journal of Molecular Sciences
C CarpénéJosé Miguel Arbones-Mainar

Abstract

Phenolic compounds are among the most investigated herbal remedies, as is especially the case for resveratrol. Many reports have shown its anti-aging properties and the ability to reduce obesity and diabetes induced by high-fat diet in mice. However, such beneficial effects hardly translate from animal models to humans. The scientific community has therefore tested whether other plant phenolic compounds may surpass the effects of resveratrol. In this regard, it has been reported that piceatannol reproduces in rodents the anti-obesity actions of its parent polyphenol. However, the capacity of piceatannol to inhibit adipocyte differentiation in humans has not been characterized so far. Here, we investigated whether piceatannol was antiadipogenic and antilipogenic in human preadipocytes. Human mesenchymal stem cells (hMSC), isolated from adipose tissues of lean and obese individuals, were differentiated into mature adipocytes with or without piceatannol, and their functions were explored. Fifty μM of piceatannol deeply limited synthesis/accumulation of lipids in both murine and hMSC-derived adipocytes. Interestingly, this phenomenon occurred irrespective of being added at the earlier or later stages of adipocyte differentiation. M...Continue Reading

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Citations

Nov 8, 2018·Nutrients·Alice ChaplinJosep Mercader
Dec 27, 2019·World Journal of Stem Cells·Yu-Hao ChengQin Bian
Feb 25, 2019·Applied Microbiology and Biotechnology·Anil ShresthaJae Kyung Sohng
Apr 20, 2019·Frontiers in Microbiology·Valeria SorrentiLuca Vanella
Jul 18, 2021·Journal of Ethnopharmacology·Anuj Kumar BorahJagat Chandra Borah

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Methods Mentioned

BETA
Assay
PCR

Software Mentioned

Graph Pad Prism R

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