The difference in hypoglycemic action between polygonati rhizoma and polygonati officinalis rhizoma

Biological & Pharmaceutical Bulletin
T Miura, A Kato

Abstract

The hypoglycemic effect of the rhizomes of Polygonatum sibricum and Polygonatum officinale (Liliaceae) was investigated in KK-Ay mice, one of the animal models of non-insulin dependent diabetes mellitus (NIDDM). The methanol extract of the rhizomes of both Polygonatum sibricum (OM) and Polygonatum officinale (IM) (800 mg/kg) reduced the blood glucose levels in KK-Ay mice 4h after intraperitoneal administration. In terms of hypoglycemic effect, the blood glucose of 1M was lower than that of OM. IM-treated mice significantly decreased the blood glucose level in an insulin tolerance test, but OM-treated mice did not change. We estimated that the hypoglycemic effect of IM raised insulin sensitivity.

Citations

Jun 18, 2002·The American Journal of Chinese Medicine·Toshihiro MiuraKeiichiro Tanigawa
Oct 21, 2014·Pharmaceutical Biology·Jong-Hee KoJae-Hoon Kang
Jun 25, 2005·Archives of Pharmacal Research·Mi-Jeong Ahn, Jinwoong Kim
Nov 8, 2005·Biological & Pharmaceutical Bulletin·Toshihiro MiuraTorao Ishida
Jun 24, 2017·Okajimas Folia Anatomica Japonica·Tomoko NozakiHiromi Ueda

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