The different dosages of estrogen affect endometrial fibrosis and receptivity, but not SDF-1/CXCR4 axis in the treatment of intrauterine adhesions

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Qin ZhouHongbo Qi

Abstract

The study was to evaluate whether fibrotic markers, endometrial receptivity markers and SDF-1/CXCR4 had been changed in the treatment of intrauterine adhesions (IUAs) by different dosages of estrogen. A total of 39 patients with IUAs were treated with EV 4 mg or 9 mg randomly post-surgery. TGF-β1/MMP-9, VEGF/αvβ3 and SDF-1/CXCR4 were detected in endometrial tissue before and after treatment by real-time PCR and Western blot. TGF-β1 and MMP-9 expression significantly decreased after treatment for 3 months than before (p < .05), the falling range was larger with EV 4 mg than 9 mg in the mild-moderate degree IUAs (p < .05); Integrin avβ3 expression significantly increased after treatment for 3 months than before (p < .05), the variation range was larger with EV 4 mg than 9 mg (p < .05); CXCR4 expression had no significant change after treatment 3 months compared to that before treatment (p > .05). SDF-1 presented an upward tendency at early phase, and it came back to the level of pre-surgery. But there were no significant difference between treatment with 4 mg and 9 mg in the rate of menstrual restoration and pregnancy follow-up 3 months after the treatment. Endometrium fibrosis may be inhibited and endometrium receptivity may be ...Continue Reading

Associated Clinical Trials

References

Jan 17, 2002·Contributions to Gynecology and Obstetrics·T RömerD Foth
Mar 4, 2003·Reproduction : the Official Journal of the Society for the Study of Fertility·Lois A Salamonsen
Feb 7, 2007·Human Reproduction·Kiyoko KatoNorio Wake
Mar 11, 2008·Fertility and Sterility·Ichiro MiwaNorihiro Sugino
Apr 15, 2008·Fertility and Sterility·Dan YuTin-Chiu Li
Jun 25, 2008·Atherosclerosis·Dick WågsäterPer Eriksson
May 12, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Tetsuo MaruyamaYasunori Yoshimura
Oct 23, 2010·Pharmacology & Therapeutics·Santhosh K GhadgeMichael Bader
Jul 23, 2011·Nephrology·Andrea F Wise, Sharon D Ricardo
Jul 26, 2011·Journal of the American Society of Nephrology : JASN·Wei QinHui Y Lan
Oct 18, 2011·Fertility and Sterility·Edward J NejatU Thomas Meier
Jun 5, 2012·Fertility and Sterility·Caroline E Gargett, Louie Ye
Jun 16, 2012·International Journal of Immunopathology and Pharmacology·R PaolilloA Rizzo
Jul 27, 2012·Journal of Spinal Disorders & Techniques·Jin-Oh ParkSeong-Hwan Moon
Jun 25, 2013·Journal of Cellular Biochemistry·Nanmei LiuJinyuan Zhang
Jul 23, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Nenghui LiuJingfeng Zhao
Sep 12, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yu XiaoYingfang Zhou
Dec 21, 2013·Fertility and Sterility·Zhao JingLi Yanping
Jan 1, 2014·Reproductive Biology and Endocrinology : RB&E·Alessandro ConfortiAdam Magos
Jun 25, 2014·Seminars in Reproductive Medicine·Emily A Evans-Hoeker, Steven L Young
Oct 8, 2014·Taiwanese Journal of Obstetrics & Gynecology·Kuan-Hao TsuiPeng-Hui Wang
Mar 17, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ai-Zhen LiuBao-Zhi Guo
Aug 4, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Yanling ZhangSongying Zhang
Sep 12, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jianmei WangYujuan Zhang

❮ Previous
Next ❯

Citations

Aug 4, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Fei ZhengYuechong Cui
May 8, 2020·American Journal of Reproductive Immunology : AJRI·Ayitila AbudukeyoumuFeng Xie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Ai-Zhen LiuBao-Zhi Guo
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Yi ZhuLina Hu
Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences
Fatemehsadat AmjadiMehdi Mehdizadeh
© 2022 Meta ULC. All rights reserved