The differential ability of the phytoestrogen genistein and of estradiol to induce uterine weight and proliferation in the rat is associated with a substance specific modulation of uterine gene expression

Molecular and Cellular Endocrinology
Patrick DielGünter Vollmer

Abstract

In this study the ability of the phytoestrogen genistein (GEN) to regulate proliferation in the rat uterine tissue and the associated molecular mechanisms were investigated in a dose and time dependent manner. A single administration of GEN induced a rapid increase of the uterine weight during the first 24 h. In contrast to E2, treatment with GEN for 3 days did not result in a further increase of the uterine weight. GEN only marginally effected the thickness of the uterine epithelium and the expression of epithelial proliferating cell nuclear antigen (PCNA). Whereas, estrogen sensitive genes were modulated significantly, the expression of key genes involved in the regulation of proliferation (PCNA, ERalpha /ERbeta ratio) remained unaffected by GEN. Our results indicate that GEN has only a limited ability to activate molecular mechanisms involved in the induction of proliferation whereas estrogen sensitive genes are induced in a estrogen like manner.

References

Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·H AdlercreutzT Hase
Feb 1, 1996·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·M J Iatropoulos, G M Williams
Feb 1, 1996·Biology of Reproduction·B S Katzenellenbogen
Aug 15, 1997·American Journal of Epidemiology·M T GoodmanL N Kolonel
Jul 11, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·N L Weigel, Y Zhang
Nov 3, 1998·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P FantiH H Malluche
Jan 30, 1999·Journal of Molecular Endocrinology·H HiroiM Muramatsu
Feb 3, 2000·Public Health Nutrition·J J AndersonS C Garner
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z WeihuaJ A Gustafsson
Oct 19, 2002·The American Journal of the Medical Sciences·Lori RussellC Andrew Brown
May 3, 2003·The American Journal of Medicine·Francesco SquadritoGiovanni Squadrito

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Citations

May 12, 2009·Nature Chemical Biology·Megan K DennisEric R Prossnitz
Mar 31, 2006·Thyroid : Official Journal of the American Thyroid Association·Mark Messina, Geoffrey Redmond
Sep 21, 2006·Journal of the National Cancer Institute·Mark MessinaJohanna W Lampe
Jun 5, 2008·Nutrition Journal·Mark J Messina, Charles E Wood
Apr 30, 2009·BMC Medical Genomics·Joshua C KwekelTimothy R Zacharewski
Jun 27, 2006·The Journal of Reproduction and Development·Hataitip TrisomboonKazuyoshi Taya
Jan 5, 2008·Environmental Health Perspectives·Guillermo RimoldiWolfgang Wuttke
Apr 10, 2013·International Journal of Medical Sciences·Naguib SallehSoh Onn Yeong
Dec 8, 2006·Bioscience, Biotechnology, and Biochemistry·Kyoka Takashima-SasakiChisato Mori
Oct 12, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Annekathrin Martina KeilerOliver Zierau
Feb 10, 2012·International Journal of Hypertension·Roxana N PeroniEdda Adler-Graschinsky
Sep 14, 2007·Climacteric : the Journal of the International Menopause Society·D RachońW Wuttke
Sep 29, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Annekathrin Martina KeilerGünter Vollmer
Feb 2, 2011·Experimental and Molecular Pathology·Brante P SampeyDavid G Kaufman
Oct 8, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Anja PapkeGünter Vollmer
May 12, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Frank Josef MöllerGünter Vollmer
Jul 3, 2007·Ageing Research Reviews·Wolfgang WuttkeDana Seidlová-Wuttke
Oct 20, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Patrick DielGünter Vollmer
Sep 29, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Antonio CaldarelliGuenter Vollmer
May 23, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hyun Ku KangMi-Sook Dong
Feb 13, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M Kaszkin-BettagP W Heger
Sep 30, 2016·Pharmacological Reviews·Birgit M DietzJudy L Bolton
Aug 16, 2005·Critical Reviews in Toxicology·Robert GoldenGuenter Vollmer
Feb 9, 2017·Journal of Applied Toxicology : JAT·Chiaki KomineMaiko Kawaguchi
Sep 21, 2006·American Journal of Physiology. Endocrinology and Metabolism·G Eda AkbasHugh S Taylor
Apr 3, 2014·Journal of Complementary & Integrative Medicine·Stéphane ZingueChantal Beatrice Magne Nde
Aug 24, 2013·Journal of Complementary & Integrative Medicine·Dieudonné NjamenBenedicta N Nkeh-Chungag

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