The differential coupling of oxytocin receptors to uterine contractions in murine estrous cycle

Biochemical and Biophysical Research Communications
Masaki KawamataKatsuhiko Nishimori

Abstract

Oxytocin (OT)-induced uterine contractility in different ovulatory phases has not been characterized in mouse. While the uterus was refractory to OT at diestrous phase, numerous contractions were observed at estrous phase. The magnitude of uterine contractile response to OT at estrous phase was larger than that at diestrous phase. There was also significant difference in the pD(2) values for OT between the samples from the two phases. However, the level of OT receptor (OTR) transcripts and proteins was equivalent at the two phases. These results suggest that OT-induced uterine contraction is not only regulated by the quantity of OTR in the non-pregnant mouse uterus.

References

Jul 1, 1976·Journal of Reproduction and Fertility·Y Ruckebusch, L Bueno
Jun 22, 1979·Science·M S SoloffM J Fernstrom
Mar 1, 1991·Journal of Reproduction and Fertility·M MaggiM Serio
Jan 1, 1991·Journal of Reproduction and Fertility·L J JennerG E Lamming
Aug 1, 1985·The Journal of Endocrinology·E L Sheldrick, A P Flint
Nov 15, 1984·American Journal of Obstetrics and Gynecology·A R FuchsM S Soloff
Feb 1, 1994·Journal of Molecular Endocrinology·K R StevensonD C Wathes
Jul 18, 2003·The Journal of Veterinary Medical Science·Takuya MurataTakashi Higuchi

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Citations

Apr 9, 2008·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·M KawamataK Nishimori
Mar 29, 2012·The Journal of Reproduction and Development·Makoto NakataNaomi Kashiwazaki
Dec 15, 2019·Biology of Reproduction·Hiroyoshi TsuchiyaTaka-Aki Koshimizu
Dec 7, 2006·American Journal of Physiology. Endocrinology and Metabolism·Masaki KawamataKatsuhiko Nishimori

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