PMID: 9556428Apr 29, 1998Paper

The differential diagnosis of pagetoid cells in the epidermis

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
S KohlerB R Smoller

Abstract

In addition to Paget's disease, a heterogeneous group of processes with diverse histogeneses can give rise to intraepidermal pagetoid cells. These diseases share as their common denominator the presence of discrete non-Malpighian or abnormal Malpighian cells occurring singly or in nests within the epidermis. Either Pagetoid cells can represent the only histologic change, as in pagetoid squamous cell carcinoma in situ or superficial spreading malignant melanoma in situ, or they can be an expression of an associated dermal or internal malignancy, as in sebaceous carcinoma or breast carcinoma. The histologic appearance of the pagetoid cells in these diverse disorders can be quite similar, rendering the differential diagnosis difficult. A review of the entities that enter into the differential diagnosis of intraepidermal pagetoid cells is presented, emphasizing their distinguishing histologic and immunophenotypic features and differential diagnosis.

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Seminars in Diagnostic Pathology
S Suster
The Journal of Dermatological Treatment
M Covadonga Martínez-GonzálezEduardo Fonseca
Archives of Pathology & Laboratory Medicine
J D WilliamsonL J Medeiros
© 2022 Meta ULC. All rights reserved