The differential effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on seizure frequency in patients with drug-resistant epilepsy - A randomized, double-blind, placebo-controlled trial

Epilepsy & Behavior : E&B
Fatma A S IbrahimAhmed A Daak

Abstract

The omega-3 (n-3) fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are known to play an important role in maintenance and modulation of neuronal functions. There is evidence that omega-3 fatty acids may have anticonvulsant effects. The effect of DHA and EPA on seizure rate in patients with drug-resistant epilepsy (DRE) was investigated. A double-blind, randomized, placebo-controlled clinical trial included ninety-nine (n = 99) subjects with DRE, aged 5-16 years (n = 85) and 17-45 years (n = 14). After randomization, subjects were given two, four, or six capsules per day of DHA (417.8 mg DHA and 50.8 mg EPA/capsule, n = 33), EPA (385.6 mg EPA and 81.2 mg DHA/capsule, n = 33), or placebo (high oleic acid sunflower oil, n = 33) for one year. The primary endpoint was the effect of treatment on rate of seizure. Random-effects negative binomial regression models were fitted to model the patients' total count of seizures per month. The treatment effects on seizure incidence rate ratio (IRR) were tested after controlling for the covariate effects of gender, age, rate of seizure per week at enrollment, type of seizure, and number of antiepileptic drug (AED) combinations used at enrollment. Fifty-nine subjects (n ...Continue Reading

Citations

Jul 2, 2019·Therapeutic Advances in Psychopharmacology·Arne Reimers, Hanna Ljung
Apr 3, 2021·Prostaglandins, Leukotrienes, and Essential Fatty Acids·N R AbukneshaK Ghebremeskel
Nov 11, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ali A Asadi-Pooya, Leila Simani
Sep 12, 2020·CNS & Neurological Disorders Drug Targets·Shareen SinghAshish Kumar Rehni

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