PMID: 6403957Jan 1, 1983Paper

The differential effects of haloperidol and methamphetamine on time estimation in the rat

Psychopharmacology
A V Maricq, R M Church

Abstract

Forty rats were trained to make a left lever response if a signal (white noise) was 2.5s and to make a right lever response if the signal was 6.3s. When seven intermediate signal durations, to which responses were not reinforced, were randomly interspersed the probability of a right-lever ('long') response increased as a function of signal duration. Methamphetamine shifted this psychometric function leftward and decreased its slope: haloperidol also decreased the slope but shifted the function rightward. A combination of haloperidol and methamphetamine led to a function similar to the saline control function. The leftward shift probably reflects an increase in the speed of an internal clock, and the rightward shift probably reflects a decrease in its speed. Since methamphetamine releases several catecholamines, including dopamine, and haloperidol blocks dopamine receptors, it is plausible that the horizontal location of the psychometric function (the speed of the clock) is related to the effective level of dopamine.

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Citations

Jul 8, 2005·Psychopharmacology·Christopher J MacDonald, Warren H Meck
Oct 3, 2007·Psychopharmacology·Irina A SukhotinaAnton Y Bespalov
May 24, 2011·Psychopharmacology·Jennifer T CoullPaul C Fletcher
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Mar 23, 2013·Behavioural Processes·Catalin V Buhusi, Sorinel A Oprisan
May 28, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Pascale C BougerFranz-Josef van der Staay
Aug 18, 2001·Pharmacology, Biochemistry, and Behavior·T OhyamaP D Balsam
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·M-Y HoE Szabadi
Aug 30, 2003·Behavioural Brain Research·Jonathon D CrystalAndrea G Hohmann
Jun 8, 2001·Behavioural Processes·J D. Crystal
Apr 12, 2002·Behavioural Processes·Amy L. Odum
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Feb 26, 2004·Behavioral Neuroscience·Matthew S MatellWarren H Meck
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Jul 30, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer T CoullWarren H Meck
Jun 18, 2005·Behavioural Pharmacology·E A McClureC D L Wynne
Sep 10, 2009·Behavioural Pharmacology·Erin A McClureClive D L Wynne

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