PMID: 6106695Aug 1, 1980Paper

The differential effects of morphine, oxotremorine and antipsychotic drugs on DOPAC concentrations in rat brain

The Journal of Pharmacy and Pharmacology
M Stanley, S Wilk

Abstract

The effects of morphine and oxotremorine on concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC) in the rat striatum and tuberculum olfactorium (TO) have been compared with the effects of the antipsychotic drugs haloperidol, chlorpromazine and clozapine. All the drugs elevated DOPAC concentrations in both brain regions. While the dose-response curves for the antipsychotic drugs were parallel, had steep slopes and similar maxima, the curves for morphine and oxotremorine were irregularly shaped but the curve for morphine in the TO had some similarity to that of the antipsychotic drugs. From these findings, it is concluded that the dose-dependent increase in striatal DOPAC effected by antipsychotic drugs can be used to differentiate them from other drugs known to elevate dopamine metabolites.

References

Jan 7, 1977·European Journal of Pharmacology·S Wilk, M Stanley
Aug 15, 1977·European Journal of Pharmacology·M Stanley, S Wilk
Jun 1, 1977·European Journal of Pharmacology·J LeysenP Laduron
Jun 1, 1975·The Journal of Pharmacy and Pharmacology·G BartholiniA Pletscher
Jul 1, 1978·The Journal of Clinical Endocrinology and Metabolism·G TolisH Guyda
Jan 1, 1978·European Journal of Pharmacology·K B KofferO Hornykiewicz
Jan 1, 1978·European Journal of Pharmacology·G M De MontisA Tagliamonte
Aug 15, 1977·European Journal of Pharmacology·F KaroumR J Wyatt
Jun 1, 1976·European Journal of Pharmacology·B H Westerink, J Korf
Feb 1, 1975·European Journal of Pharmacology·S WilkB Travis
Apr 1, 1973·The Journal of Pharmacy and Pharmacology·N E Andén, G Stock
Jan 1, 1974·European Journal of Pharmacology·T Nose, H Takemoto
Jul 1, 1972·European Journal of Pharmacology·K Kuschinsky, O Hornykiewicz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here