The differential effects of pathway- versus target-derived glial cell line-derived neurotrophic factor on peripheral nerve regeneration.

Journal of Neurosurgery
Christina K MagillSusan E Mackinnon

Abstract

Glial cell line-derived neurotrophic factor (GDNF) has potent survival effects on central and peripheral nerve populations. The authors examined the differential effects of GDNF following either a sciatic nerve crush injury in mice that overexpressed GDNF in the central or peripheral nervous systems (glial fibrillary acidic protein [GFAP]-GDNF) or in the muscle target (Myo-GDNF). Adult mice (GFAP-GDNF, Myo-GDNF, or wild-type [WT] animals) underwent sciatic nerve crush and were evaluated using histomorphometry and muscle force and power testing. Uninjured WT animals served as controls. In the sciatic nerve crush, the Myo-GDNF mice demonstrated a higher number of nerve fibers, fiber density, and nerve percentage (p < 0.05) at 2 weeks. The early regenerative response did not result in superlative functional recovery. At 3 weeks, GFAP-GDNF animals exhibit fewer nerve fibers, decreased fiber width, and decreased nerve percentage compared with WT and Myo-GDNF mice (p < 0.05). By 6 weeks, there were no significant differences between groups. Peripheral delivery of GDNF resulted in earlier regeneration following sciatic nerve crush injuries than that with central GDNF delivery. Treatment with neurotrophic factors such as GDNF may offer...Continue Reading

References

Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R EftimieA Buonanno
Jan 1, 1990·Annual Review of Neuroscience·J W Fawcett, R J Keynes
Jun 1, 1994·Experimental Neurology·P M BridgeC Hertl
Feb 3, 1999·The Journal of Surgical Research·K YoshimuraW M Kuzon
Mar 24, 1999·Journal of Reconstructive Microsurgery·M S UrbanchekW M Kuzon
Apr 2, 1999·Molecular & General Genetics : MGG·A Krempler, B Brenig
Dec 26, 2001·Muscle & Nerve·Loree K KalliainenWilliam M Kuzon
Mar 12, 2002·The European Journal of Neuroscience·Eric G FinePatrick Aebischer
Jan 18, 2003·Brain Research. Molecular Brain Research·Matthias TiteuxDenise Paulin
Nov 9, 2004·Experimental Neurology·Martha C Bohn
Dec 8, 2004·Mechanisms of Development·Jennifer WhiteheadWarren G Tourtellotte
Sep 12, 2006·Experimental Neurology·Michael F SalvatoreDon M Gash
Sep 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·A HökeT M Brushart
Oct 20, 2006·Nature Chemical Biology·Douglas A Lauffenburger
Aug 7, 2007·Journal of Neuroscience Methods·Daniel A HunterSusan E Mackinnon
Jun 6, 2008·Neuroscience Research·Jun-Ping CaoDian-Shuai Gao
Jul 4, 2008·Trends in Neurosciences·Gustavo Paratcha, Fernanda Ledda
Jan 1, 1989·The Western Journal of Medicine·V R Hentz

❮ Previous
Next ❯

Citations

Sep 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Bogdan BeirowskiJeffrey Milbrandt
Mar 25, 2011·British Medical Bulletin·Pilar Martínez de AlbornozNicola Maffulli
Jan 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Kristian L HedstromGabriel Corfas
Dec 17, 2014·Experimental Neurology·Laura M Marquardt, Shelly E Sakiyama-Elbert
Apr 15, 2014·Biotechnology and Bioengineering·Yuewei Wu-FienbergMatthew D Wood
Oct 1, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Jin-Yong LeeJong-Ho Lee
Mar 15, 2014·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Jin-Yong LeeJong-Ho Lee
Apr 2, 2013·Plastic and Reconstructive Surgery·Ying YanPhilip J Johnson

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
force measurements
enzyme-linked immunosorbent assay
confocal microscopy

Software Mentioned

DMC
MATLAB
DMA
Statistica

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.