PMID: 11314679Apr 21, 2001Paper

The differential effects of prenatal stress in rats on the acoustic startle reflex under baseline conditions and in response to anxiogenic drugs

Psychopharmacology
D A White, Dale L Birkle

Abstract

The prenatal stress syndrome (PS) is characterized by exaggerated behavioral and physiological responses to stressful stimuli and anxiogenic agents. To characterize the behavioral effects of PS on the acoustic startle reflex (ASR) and to determine the possible role of PS-induced alterations in noradrenergic control of ASR by determining the effects of the alpha2-adrenoceptor antagonists, yohimbine, idazoxan, and RS79948-197. PS was induced by exposing pregnant dams to a mild stressor of handling and saline injection (0.1 ml, s.c.) from gestational days 14 to 21. Control dams were left undisturbed throughout pregnancy. Using adult male offspring, all ASR studies consisted of either a 30- or 60-min testing period containing 60 or 120 acoustic startle stimuli trials (95 dB, 50 ms noise burst) at a fixed intertrial interval of 30 s after a 5-min acclimation period. For drug studies, a 3-day repeated measures design was implemented. With the exception of the response to the first startle stimulus on the first day of testing, there were no significant differences in baseline ASR between control and PS offspring. Low doses of yohimbine, idazoxan, and RS79948-197 were anxiogenic in the ASR test in both control and PS offspring. PS offs...Continue Reading

Citations

Jun 4, 2005·Pharmacology, Biochemistry, and Behavior·W C GriffinD L Birkle
Jul 18, 2002·Behavioural Pharmacology·P Willner, P J Mitchell
Dec 28, 2012·Behavioural Pharmacology·Mate TothVictoria Risbrough
Jul 2, 2014·Neurobiology of Learning and Memory·Antonella GasbarriCarlos Tomaz
Jul 18, 2012·Behavioural Brain Research·Kah-Chung LeongMark G Packard
Jan 10, 2009·Behavioural Brain Research·Mark G Packard
Jul 30, 2008·Neurobiology of Learning and Memory·Audrea E Elliott, Mark G Packard
Sep 6, 2008·Neuroscience and Biobehavioral Reviews·Francesca MastorciAndrea Sgoifo
Jun 21, 2008·Behavioural Brain Research·Jeffrey C Wingard, Mark G Packard
Sep 19, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Irene Gracia-RubioOlga Valverde
Aug 10, 2013·Hippocampus·Mark G Packard, Jarid Goodman
Mar 14, 2007·Progress in Neurobiology·Fabio FumagalliMarco Andrea Riva
Oct 18, 2005·The Journal of Comparative Neurology·Elizabeth A MyersLinda Rinaman
Feb 1, 2005·Neurotoxicology and Teratology·Karin S HougaardSøren P Lund
Oct 7, 2004·Neurobiology of Learning and Memory·Mark G Packard, Jeffrey C Wingard
Aug 9, 2005·Brain Research. Developmental Brain Research·Karin S HougaardSøren P Lund
Feb 12, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Buyean LeeRoger D Spealman
Mar 25, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Janne LähdesmäkiMika Scheinin
Mar 5, 2020·The International Journal of Neuroscience·Samaneh GhotbiRavandiMasoumeh Nozari

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