The differential effects of thiazolidindiones on atherogenic dyslipidemia in type 2 diabetes: what is the clinical significance?

Expert Opinion on Pharmacotherapy
Manfredi RizzoKaspar Berneis

Abstract

Diabetic dyslipidemia is typically characterized by an increase in plasma triglycerides, a decrease in high-density lipoprotein cholesterol and a concomitant increase in atherogenic small dense low-density lipoproteins. Thiazolidindiones are able to lower the levels of fasting glucose and glycated hemoglobin significantly by improving insulin sensitivity, as well as improving some aspects of diabetic dyslipidemia: total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol tend to increase while triglycerides are generally decreased. This paper reviewed the effects of pioglitazone and rosiglitazone on atherogenic diabetic dyslipidemia, in particular on small dense low-density lipoprotein particles. A literature search (by Medline and Scopus) was performed up to 15 March 2008. The authors also manually reviewed the references of selected articles for any pertinent material. Pioglitazone showed an additional beneficial effect on triglycerides, high-density lipoprotein cholesterol and the levels of small dense low-density lipoprotein compared to rosiglitazone. Since recent studies have suggested that these agents may also have a differential effect on long-term cardiovascular end-points despite ...Continue Reading

References

Dec 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·K R FeingoldR M Krauss
Nov 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J L WoffordJ R Crouse
Jul 1, 1993·The Journal of Clinical Investigation·G M ReavenR M Krauss
Jan 23, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·C J Packard, J Shepherd
Oct 9, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·K OkumuraT Ito
Jan 15, 2000·Diabetes/metabolism Research and Reviews·M D FeherC J Packard
Nov 30, 2000·Biochemical and Biophysical Research Communications·J SakamotoH Sawada
May 16, 2001·Current Opinion in Lipidology·N S Shachter
Jul 10, 2001·The Journal of Clinical Endocrinology and Metabolism·H KoshiyamaY Nakamura
May 8, 2002·Diabetes/metabolism Research and Reviews·Francisco J Gómez-PerezErrol M Gould
Jun 12, 2002·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·H C GeissK G Parhofer
Aug 30, 2002·Metabolism: Clinical and Experimental·Jianqiu PanM Arthur Charles
Oct 26, 2002·The American Journal of Cardiology·Martin I FreedUNKNOWN Rosiglitazone Study 108 investigators
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Ana M WägnerAntonio Pérez
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·Frank M Sacks, Hannia Campos
Nov 19, 2003·Current Opinion in Lipidology·Michel Narce, Jean-Pierre Poisson
Apr 2, 2004·Nature Medicine·Ronald M EvansYong-Xu Wang
May 8, 2004·American Heart Journal·Abdulfatah OsmanBarry F Uretsky
May 27, 2004·Diabetes Care·Ronald M Krauss
Sep 18, 2004·Metabolism: Clinical and Experimental·Tsukasa NakamuraHikaru Koide
Oct 27, 2004·Archives of Internal Medicine·Elaine ChiquetteRalph Defronzo
Nov 16, 2004·Trends in Endocrinology and Metabolism : TEM·Lina Zhang, Ajay Chawla
Jan 22, 2005·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·K G ParhoferB Göke

❮ Previous
Next ❯

Citations

Oct 17, 2008·Cardiovascular Diabetology·M CarruthersA M Traish
Jan 1, 2009·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Giuseppe Derosa, Sibilla At Salvadeo
Jan 30, 2013·Expert Opinion on Therapeutic Targets·Sana KhanAbul Kalam Najmi
May 23, 2013·Expert Opinion on Therapeutic Targets·Manfredi RizzoAli A Rizvi
Jan 16, 2019·Expert Review of Clinical Pharmacology·Angelo Maria PattiAli A Rizvi
Apr 1, 2020·Journal of Clinical Medicine·Angelo Maria PattiFerdinando Mannello
May 1, 2021·International Journal of Molecular Sciences·Rosaria Vincenza GiglioManfredi Rizzo

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.