The differential effects of two sodium channel modulators on the conductive properties of C-fibers in pig skin in vivo

Anesthesia and Analgesia
Otilia ObrejaMartin Schmelz

Abstract

Axonal sodium channels are attractive targets for chronic pain treatment, and recent evidence suggests that specific targeting of the slow inactivation of sodium channels (NaV) might exert analgesic effects. Using a human-like animal model, the pig, we compared changes in the conductive properties of different C-fiber classes on acute administration of lidocaine (nonselective NaV blocker) and lacosamide (selective enhancer of NaV slow inactivation). Single-fiber extracellular recordings from saphenous nerves were performed. We classified C-fibers according to mechanical responsiveness and amount of activity-dependent slowing (ADS) of conduction velocity. Lidocaine (4 mM; 100 μL), lacosamide (4 mM; 100 μL), or saline was injected intradermally at the stimulation site, and changes of fibers' conductive properties were assessed. Conduction latencies evoked by lidocaine were more prominent in mechanosensitive (5.5%± 2.1%) than in mechano-insensitive nociceptors (2.5% ± 1%), whereas lacosamide increased conduction latencies to a greater extent in the mechano-insensitive (3% ± 1%) than in mechanosensitive C-nociceptors (2% ± 0.9%). Lidocaine, but not lacosamide, increased electrical thresholds in all mechanosensitive, but not in the ...Continue Reading

References

May 1, 1979·The Journal of Physiology·S A Raymond
Jan 1, 1991·Annals of the New York Academy of Sciences·X T GuoG R Strichartz
Feb 28, 1986·Neuroscience Letters·W EndresG ten Bruggencate
Jun 1, 1974·Journal of Neurology, Neurosurgery, and Psychiatry·H E Torebjörk, R G Hallin
Jun 1, 1967·The Journal of Physiology·P R Burgess, E R Perl
Apr 1, 1995·The Journal of General Physiology·M E BräuW Vogel
Jan 1, 1995·Experimental Brain Research·M SchmelzH E Torebjörk
Jun 6, 1997·The Journal of Biological Chemistry·L SangameswaranJ C Hunter
Aug 16, 2000·The Journal of Physiology·C WeidnerH E Torebjörk
Mar 4, 2003·Journal of Neurophysiology·M SchmelzH O Handwerker
Apr 20, 2006·Neuropharmacology·Adam C ErringtonGeorge Lees
Jan 24, 2007·The Clinical Journal of Pain·Richard L RauckBrigitte Koch
May 10, 2007·Muscle & Nerve·Gila Moalem-TaylorPeter Grafe
Dec 10, 2008·The Journal of Physiology·B NamerH O Handwerker
Dec 24, 2008·Expert Review of Neurotherapeutics·Ahmad BeydounPamela Doty
Feb 23, 2010·Pflügers Archiv : European journal of physiology·Katrin KistnerAndreas Leffler

❮ Previous
Next ❯

Citations

Feb 26, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Minori KodairaRyusuke Kakigi
Feb 21, 2013·Neuromodulation : Journal of the International Neuromodulation Society·Nisha VastaniKonrad Maurer
Jan 27, 2017·Journal of Neurophysiology·Roger H WatkinsRochelle Ackerley
Mar 3, 2020·Frontiers in Cellular Neuroscience·Robin JonasMartin Schmelz
Dec 2, 2020·Pain·Anthony J Burand, Cheryl L Stucky

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.