The Differential Expression of Adhesion Molecule and Extracellular Matrix Genes in Mesenchymal Stromal Cells after Interaction with Cord Blood Hematopoietic Progenitors

Doklady. Biochemistry and Biophysics
L B BuravkovaA I Grigoriev

Abstract

The dynamics of the expression of genes encoding adhesion molecules, molecules of the connective tissue matrix, and its remodeling enzymes was studied in multipotent mesenchymal stromal cells (MSCs) from human adipose tissue after interaction with cord blood hematopoietic progenitors (HSPCs). An upregulation of ICAM1 and VCAM1, directly proportional to the coculture time (24-72 h), was found. After 72 h of culturing, a downregulation of the genes encoding the majority of matrix molecules (SPP1; COL6A2,7A1; MMP1,3; TIMP1,3; and HAS1) and cell-matrix adhesion molecules (ITGs) was revealed. The detected changes may ensure the realization of the stromal MSC function due to improvement of adhesion and transmigration of HSPCs into the subcellular space.

References

Jun 2, 2005·The Journal of Experimental Medicine·Sebastian StierDavid T Scadden
May 13, 2009·Journal of Cellular and Molecular Medicine·Thomas WalendaWolfgang Wagner
Jan 1, 2008·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Wolfgang WagnerAnthony D Ho
Dec 1, 2011·International Journal of Hematology·Ana-María Perdomo-Arciniegas, Jean-Paul Vernot
Jul 6, 2014·Cell Death and Differentiation·C RietherA F Ochsenbein
Nov 3, 2015·Archives of Medical Research·Guadalupe R Fajardo-OrduñaJuan J Montesinos

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Citations

May 19, 2019·International Journal of Molecular Sciences·Dariusz BoruczkowskiIzabela Zdolińska-Malinowska

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