The Differential Expression Profiles of miRNA-let 7a, 7b, and 7c in Bronchoalveolar Lavage Fluid From Infants With Asthma and Airway Foreign Bodies

Journal of Evidence-based Integrative Medicine
Hang-Hu ZhangLan-Fang Tang

Abstract

The aim of this study was to investigate the expression patterns of miRNA-let 7a, 7b, and 7c in bronchoalveolar lavage fluid in infants with asthma and airway foreign bodies. Between January 2016 and February 2017, 27 infants were included and divided into observation group (infants with asthma, n = 15) and control group (infants with airway foreign bodies, n = 12). The differential expression profiles of miRNA-let 7a, 7b, and 7c were determined by reverse transcription-polymerase chain reaction in bronchoalveolar lavage fluid (BALF) from infants of the 2 groups. The BALF was collected from infants undergoing flexible bronchoscopy. MiRNA-let 7a, 7b, and 7c increased significantly in infants from observation group as compared with control group (2.72 ± 0.48 vs 1, 8.23 ± 1.64 vs 1, 3.16 ± 0.62 vs 1, respectively). The increased expression of miRNA-let 7a, 7b, and 7c were associated with the asthma of infants.

References

Apr 24, 2001·Archives of Disease in Childhood·D PayneA Bush
Sep 9, 2008·Trends in Cell Biology·Sarah Roush, Frank J Slack
May 19, 2010·Expert Review of Clinical Immunology·Claus Kroegel
Jul 16, 2010·The Journal of Biological Chemistry·Sumanth PolikepahadDavid B Corry
Nov 3, 2010·American Journal of Respiratory and Critical Care Medicine·Geert R Van PottelbergeGuy G Brusselle
Jun 9, 2012·American Journal of Respiratory Cell and Molecular Biology·Melanie J JardimDavid Diaz-Sanchez
Jan 22, 2013·The Journal of Allergy and Clinical Immunology·Bettina LevänenÅsa M Wheelock
Mar 13, 2014·Pneumonologia i alergologia polska·Maciej Kupczyk, Piotr Kuna
Jun 10, 2014·Clinical Therapeutics·Yu FujitaTakahiro Ochiya
Jun 15, 2014·Paediatric Respiratory Reviews·Lianne S KopelJonathan M Gaffin
Jan 1, 2012·MicroRNA·Jen-Liang SuMin-Liang Kuo
Aug 19, 2014·Scientific Reports·Matija RijavecMateja Marc Malovrh
Apr 17, 2015·Journal of Cancer Research and Therapeutics·Rajiv Sarin
May 10, 2016·Journal of Occupational and Environmental Medicine·Yang ZhangYajia Lan
Sep 3, 2016·Current Allergy and Asthma Reports·Eishika Dissanayake, Yuzaburo Inoue
Dec 16, 2017·The European Respiratory Journal·Ernst EberFabio Midulla

❮ Previous
Next ❯

Citations

Nov 27, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Weiqi ZhaiMichael Roth
Jan 23, 2021·International Journal of Molecular Sciences·José A CañasVictoria del Pozo

❮ Previous
Next ❯

Methods Mentioned

BETA
bronchoalveolar lavage
biopsy
lavage
biopsies

Software Mentioned

SPSS

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.