The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis

Stem Cells International
Jiang WuZhongjun Li

Abstract

Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs). However, how BMSC differentiation affects hematopoiesis is poorly understood. In this review, we focus on the role of BMSC differentiation in hematopoiesis. We discussed the role of BMSCs and their progeny in hematopoiesis. We also examine the mechanisms that cause differentiation bias of BMSCs in stress conditions including aging, irradiation, and chemotherapy. Moreover, the differentiation balance of BMSCs is crucial to hematopoiesis. We highlight the negative effects of differentiation bias of BMSCs on hematopoietic recovery after bone marrow transplantation. Keeping the differentiation balance of BMSCs is critical for hematopoietic recovery. This review summarises current understanding about how BMSC differentiation affects hematopoiesis and its potential application in improving hematopoietic recovery after bone marrow transplantation.

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Citations

Jul 23, 2019·International Journal of Radiation Biology·Laura M CalviJames Palis
Apr 21, 2019·International Journal of Molecular Sciences·Ahmed Abdal DayemAnd Ssang-Goo Cho
Jan 12, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marina GerguesPranela Rameshwar
Feb 28, 2020·Clinical Interventions in Aging·Qingqing YinXunyao Hou
Jan 10, 2020·Bioscience, Biotechnology, and Biochemistry·Yali ZhangJieping Chen
Apr 2, 2019·Journal of Alzheimer's Disease : JAD·Jun YuanJunjie Gao
Nov 13, 2020·Frontiers in Cell and Developmental Biology·Lin RenJuan Xia
Feb 9, 2021·Cytokine & Growth Factor Reviews·Leane Perim RodriguesJuliana Lott Carvalho
Jun 3, 2021·International Journal of Molecular Sciences·Elise AasebøØystein Bruserud
Sep 22, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zilong YaoBin Yu

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Methods Mentioned

BETA
transgenic

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