The diffusing capacity of the lung for carbon monoxide is associated with the histopathological aggressiveness of lung adenocarcinoma

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Naoki OzekiKohei Yokoi

Abstract

The diffusing capacity of the lung for carbon monoxide (DLCO) is an indicator of lung damage. We sought to determine whether DLCO is associated with the aggressiveness of lung adenocarcinoma using histopathological indexes, such as tumour differentiation, scar grade, nuclear atypia and the mitotic index. Fifty-seven patients with low DLCO (≤80% of predicted) and 466 patients with normal DLCO (>80% of predicted) who underwent R0 resection of lung adenocarcinoma between 2005 and 2012 were retrospectively reviewed. The relationships between the DLCO status and each histopathological index as well as the overall survival were evaluated. Low DLCO had significant relationships with moderate/poor differentiation (79% vs 57% [low DLCO vs normal DLCO]), scar grade 3/4 (37% vs 18%), nuclear atypia 3 (65% vs 30%) and the mitotic index 3 (26% vs 8%). After adjusting for the age, sex, forced expiratory volume in 1 s, smoking status and tumour size, a low DLCO still showed a significant correlation with the histopathological indexes. These histopathological indexes were all significant factors for the overall survival on log-rank tests. In a multivariable Cox regression analysis with 13 clinicopathological variables, moderate/poor differenti...Continue Reading

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Citations

Dec 1, 2017·International Journal of Clinical Oncology·Naoki OzekiKohei Yokoi
Aug 8, 2020·General Thoracic and Cardiovascular Surgery·Naoki OzekiToyofumi Fengshi Chen-Yoshikawa
Jan 20, 2020·International Journal of Clinical Oncology·Naoki OzekiToyofumi Fengshi Chen-Yoshikawa
Jul 28, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Nancy G CasanovaJoe G N Garcia
Mar 6, 2021·Journal of Cachexia, Sarcopenia and Muscle·Shinya TanakaToyofumi Fengshi Chen-Yoshikawa
Apr 14, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ryu KanzakiYasushi Shintani
Aug 28, 2021·Biomedicines·Diana C Sanchez-RamirezRodrigo Torres-Castro

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