PMID: 37887May 1, 1979

The digestion of pectin in the human gut and its effect on calcium absorption and large bowel function

The British Journal of Nutrition
J H CummingsM J Hill


1. The effect of dietary fibre digestion in the human gut on its ability to alter bowel habit and impair mineral absorption has been investigated using the technique of metablic balance. 2. Five healthy male students were studied for 9 weeks under controlled dietary conditions and during the last 6 weeks they took 36 g pectin/d. Bowel habit, transit through the gut, faecal fibre excretion, calcium balance and faecal composition were measured. 3. During the control period only 15% of the dietary fibre ingested was excreted in the stools and when pectin was added to the diet there was no increase in fibre excretion. Stool frequency and mean transit time were unchanged by pectin but stool wet weight increased by 33% and faecal excretion increased (%) for fatty acids 80, nitrogen 47, total dry matter 28 and bile acids 35. Ca balance remained unchanged. 4. It may be concluded from these results that dietary fibre is largely metabolized in the human gut and dietary pectin completely so. This could explain its lack of effect on bowel habit and Ca balance. Other changes in the faeces may be related to an increase in bacterial mass.


May 1, 1989·Calcified Tissue International·E Barrett-Connor
Jan 1, 1987·Molecular Aspects of Medicine·M H Ornstein, I M Baird
Mar 9, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S M MurrayK A Garleb
Jan 16, 2003·International Journal of Pharmaceutics·Tae Hee KimChong Su Cho
Dec 6, 2007·European Journal of Clinical Nutrition·M Elia, J H Cummings
May 11, 2000·The New England Journal of Medicine·M ChandaliaL J Brinkley
May 1, 1982·The British Journal of Nutrition·M Nyman, N G Asp
Nov 1, 1982·The British Journal of Nutrition·P A Judd, A S Truswell
Sep 1, 1983·The British Journal of Nutrition·L C HillmanE W Pomare
May 1, 1984·The British Journal of Nutrition·J N ThomasJ A Story
Jan 1, 1985·The British Journal of Nutrition·M I McBurneyP J Van Soest
May 1, 1985·The British Journal of Nutrition·P A Judd, A S Truswell
May 1, 1986·The British Journal of Nutrition·M NymanH Wiggins
Jul 1, 1989·The British Journal of Nutrition·M P WaltersS T Srinivasan
May 1, 1992·The British Journal of Nutrition·L BravoI Goni
May 1, 1993·The British Journal of Nutrition·R KohenA Rubinstein
Jan 1, 1992·Nutrition Research Reviews·G Livesey
Jan 1, 1984·The Proceedings of the Nutrition Society·J H Cummings
Jan 1, 1993·Critical Reviews in Food Science and Nutrition·M Roberfroid
Jan 1, 1994·Critical Reviews in Food Science and Nutrition·A M Stephen
Sep 1, 1981·Gut·J H Cummings
Aug 1, 1984·Gut·J H Cummings
Jan 1, 1986·Gut·A V Kurpad, P S Shetty
Feb 1, 1989·Gut·D B Silk
Nov 1, 1984·Postgraduate Medical Journal·J H Cummings
May 1, 1985·The Journal of Clinical Investigation·E W PomareJ H Cummings
Nov 1, 1991·Indian Journal of Pediatrics·M K Bhan, S Bhatnagar
Jan 1, 1987·Molecular Aspects of Medicine·M Eastwood
Sep 4, 2007·Digestive Diseases and Sciences·Kazuma DanjoTakashi Umeda
Jan 1, 1994·Pharmacology & Therapeutics·R C Spiller
Jul 1, 1995·Plant Foods for Human Nutrition·S Joshi, V Agte
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·R R Selvendran


May 17, 1975·Lancet·D J JenkinsJ H Cummings
Mar 25, 1978·Lancet·W P JamesD A Southgate
Feb 1, 1979·Journal of Human Nutrition·S Bingham
Feb 1, 1977·The American Journal of Clinical Nutrition·R M Kay, A S Truswell
Jul 6, 1978·Nature·D A SouthgateJ Robertson
Oct 1, 1978·The American Journal of Clinical Nutrition·D A Southgate
Oct 1, 1978·The American Journal of Clinical Nutrition·J H Cummings
Jan 1, 1977·Annals of Internal Medicine·D J JenkinsG M Alberti
Sep 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·T A Miettinen, S Tarpila
Oct 1, 1976·Metabolism: Clinical and Experimental·D A SouthgateI M Baird
Dec 1, 1976·The American Journal of Clinical Nutrition·J H CummingsH Wiggins
Jun 1, 1966·The American Journal of Clinical Nutrition·G H Palmer, D G Dixon
Nov 1, 1970·The American Journal of Clinical Nutrition·R H McBee
Jul 1, 1969·The American Journal of Physiology·H C Harrison, H E Harrison
Jun 1, 1969·Journal of the Science of Food and Agriculture·D A Southgate
Mar 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·A KEYSJ T ANDERSON
Jun 2, 1942·The Journal of Physiology·R A McCance, E M Widdowson
Nov 30, 1942·The Journal of Physiology·R A McCance, E M Widdowson

Related Concepts

Large Intestine
Gamma-glutamyl transferase
Calcium, Dietary
Intestinal Motility
Intestinal Absorption

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.