The Digital Slide Archive: A Software Platform for Management, Integration, and Analysis of Histology for Cancer Research

Cancer Research
David A GutmanLee A D Cooper

Abstract

Tissue-based cancer studies can generate large amounts of histology data in the form of glass slides. These slides contain important diagnostic, prognostic, and biological information and can be digitized into expansive and high-resolution whole-slide images using slide-scanning devices. Effectively utilizing digital pathology data in cancer research requires the ability to manage, visualize, share, and perform quantitative analysis on these large amounts of image data, tasks that are often complex and difficult for investigators with the current state of commercial digital pathology software. In this article, we describe the Digital Slide Archive (DSA), an open-source web-based platform for digital pathology. DSA allows investigators to manage large collections of histologic images and integrate them with clinical and genomic metadata. The open-source model enables DSA to be extended to provide additional capabilities. Cancer Res; 77(21); e75-78. ©2017 AACR.

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Citations

Feb 7, 2019·Bioinformatics·Mohamed AmgadLee A D Cooper
Oct 2, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ramraj ChandradevanDavid L Jaye
Feb 16, 2019·Transplantation·Michelle A Wood-TrageserAnthony J Demetris
Mar 7, 2020·JCO Clinical Cancer Informatics·Hayley M DingerdissenRaja Mazumder
Jun 20, 2020·Clinical Pharmacology and Therapeutics·Sebastien Benzekry
Jan 8, 2019·F1000Research·Roderic Guigo, Michiel de Hoon
Jul 18, 2020·Frontiers in Oncology·Luyuan ZhangDavid Gutman
Mar 14, 2018·Proceedings of the National Academy of Sciences of the United States of America·Pooya MobadersanyLee A D Cooper
Apr 30, 2020·Acta Neuropathologica Communications·Juan C VizcarraDavid A Gutman
Oct 12, 2018·JAMA Dermatology·Caroline C KimUNKNOWN Pigmented Lesion Subcommittee, Melanoma Prevention Working Group
Dec 5, 2019·Frontiers in Medicine·Raphaël Marée
Dec 24, 2020·Cancer Research·Sanghoon LeeLee A D Cooper
Feb 25, 2021·Journal of the American Society of Nephrology : JASN·Brandon GinleyPinaki Sarder
Sep 5, 2021·Journal of the American Society of Nephrology : JASN·Darshana GovindPinaki Sarder
Jan 5, 2022·Journal of Neuropathology and Experimental Neurology·Mustafa N Shakir, Brittany N Dugger

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