The 'Digital Twin' to enable the vision of precision cardiology.

European Heart Journal
Jorge Corral-AceroPablo Lamata

Abstract

Providing therapies tailored to each patient is the vision of precision medicine, enabled by the increasing ability to capture extensive data about individual patients. In this position paper, we argue that the second enabling pillar towards this vision is the increasing power of computers and algorithms to learn, reason, and build the 'digital twin' of a patient. Computational models are boosting the capacity to draw diagnosis and prognosis, and future treatments will be tailored not only to current health status and data, but also to an accurate projection of the pathways to restore health by model predictions. The early steps of the digital twin in the area of cardiovascular medicine are reviewed in this article, together with a discussion of the challenges and opportunities ahead. We emphasize the synergies between mechanistic and statistical models in accelerating cardiovascular research and enabling the vision of precision medicine.

References

Apr 1, 1990·Journal of the American College of Cardiology·F AlfonsoW J McKenna
Dec 5, 2006·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Antonio PellicciaSilvia Priori
Aug 21, 2008·IEEE Transactions on Bio-medical Engineering·Oliver StegleSøren Brage
May 16, 2009·Journal of Diabetes Science and Technology·Boris P KovatchevClaudio Cobelli
Oct 19, 2010·Cardiovascular Research·Steven A NiedererNicolas P Smith
Oct 5, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Steven A NiedererNic P Smith
Nov 2, 2012·Science Translational Medicine·Raimond L WinslowMichael I Miller
Feb 5, 2013·Journal of Cardiovascular Electrophysiology·Michel HaissaguerreRemi Dubois
May 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·Oliver J BrittonBlanca Rodriguez
Jan 1, 2014·Frontiers in Physiology·Pras Pathmanathan, Richard A Gray
Jan 9, 2015·The Journal of Experimental Biology·Denis Noble
Jan 27, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·David AndreuAntonio Berruezo
Jan 31, 2015·The New England Journal of Medicine·Francis S Collins, Harold Varmus
Jun 29, 2015·JACC. Cardiovascular Interventions·Paul D MorrisJulian P Gunn
Jul 15, 2015·Journal of Pharmacological and Toxicological Methods·Icilio Cavero, Henry Holzgrefe
Sep 20, 2015·Journal of Molecular and Cellular Cardiology·Elisa PassiniAlfonso Bueno-Orovio
Sep 27, 2015·Medical Image Analysis·Fabrizio DonatiDavid A Nordsletten
Sep 30, 2015·Biomechanics and Modeling in Mechanobiology·Desmond Dillon-MurphyC Alberto Figueroa
Jan 26, 2016·Proceedings. Mathematical, Physical, and Engineering Sciences·Sander LandSteven A Niederer
Feb 13, 2016·JAMA : the Journal of the American Medical Association·Alison M DarcyLaura Weiss Roberts
Feb 20, 2016·Drug Discovery Today·Mark R DaviesLiudmila Polonchuk
Mar 12, 2016·JACC. Cardiovascular Interventions·Peter de JaegerePeter Mortier
Mar 19, 2016·The Journal of Physiology·Gary R MiramsRichard H Clayton
Mar 20, 2016·American Journal of Epidemiology·Miguel A Hernán, James M Robins
Mar 25, 2016·Nature Reviews. Cardiology·John S RumsfeldThomas M Maddox
May 11, 2016·Nature Communications·Hermenegild J ArevaloNatalia A Trayanova
Jun 11, 2016·Journal of Pharmacological and Toxicological Methods·Thomas ColatskyNorman Stockbridge
Jul 1, 2016·Nature Reviews. Cardiology·Elliott M Antman, Joseph Loscalzo
Sep 7, 2016·Pharmacology & Therapeutics·Junko KurokawaTetsushi Furukawa
Jan 18, 2017·Circulation. Cardiovascular Imaging·Fabrizio DonatiPablo Lamata
Mar 11, 2017·Journal of Biopharmaceutical Statistics·Tarek HaddadUNKNOWN MDIC Computer Modeling and Simulation Working Group Participants
Apr 6, 2017·The New England Journal of Medicine·Owen Faris, Jeffrey Shuren
May 24, 2017·Frontiers in Bioengineering and Biotechnology·Carlos SánchezBlanca Rodríguez

❮ Previous
Next ❯

Citations

Aug 28, 2020·Frontiers in Cardiovascular Medicine·Karim LekadirSteffen E Petersen
Dec 9, 2020·Surgical Innovation·Hanad Ahmed, Laurence Devoto
Jan 12, 2021·Anaesthesia·M McKendrickG A McLeod
Dec 29, 2020·Computer Methods and Programs in Biomedicine·Cong ZhouThomas Desaive
Feb 14, 2021·Biomechanics and Modeling in Mechanobiology·M PeirlinckE Kuhl
Mar 10, 2021·European Heart Journal·Massimiliano GnecchiPeter J Schwartz
Feb 18, 2021·Pacing and Clinical Electrophysiology : PACE·Stefano PaganiAlfio Quarteroni
Mar 14, 2021·Nature Reviews. Cardiology·Maxime SermesantNicholas Ayache
Apr 9, 2021·Advances in Therapy·Amedeo LonardoMarco Arrese
May 12, 2021·Proceedings of the National Academy of Sciences of the United States of America·J MasisonR Laubenbacher
May 19, 2021·Annals of Biomedical Engineering·Ramtin GharleghiSusann Beier
Jun 3, 2021·European Heart Journal·Faiez ZannadJaved Butler
May 21, 2021·Frontiers in Immunology·Isabel VoigtTjalf Ziemssen
May 20, 2021·European Heart Journal·Filippo Crea
Jun 26, 2021·Computer Methods and Programs in Biomedicine·Gernot PlankEdward J Vigmond
Jun 18, 2021·Cardiac Failure Review·José Silva-CardosoEmília Moreira
Jul 20, 2021·Cardiovascular Research·Wahbi K El-BouriGregory Y H Lip
Jun 26, 2021·International Journal for Numerical Methods in Biomedical Engineering·Thomas GranditsSimone Pezzuto
Jul 24, 2021·Biomedical Engineering Online·Ekaterina KovachevaAxel Loewe
Aug 28, 2021·Journal of Personalized Medicine·Maged N Kamel Boulos, Peng Zhang
Sep 24, 2021·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Rafael BeyarNico Bruining
Sep 30, 2021·International Journal for Numerical Methods in Biomedical Engineering·Yang ZhouBeibei Sun
Sep 13, 2021·The Journal of Physiology·Edith JonesBrian E Carlson

❮ Previous
Next ❯

Software Mentioned

CardioInsight
HeartFlow

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Related Papers

Therapie der Gegenwart
L T Fitzgerald, W Mauderli
Journal of Postgraduate Medicine
S B Verma
Journal of the American Optometric Association
A A Rosenbloom
© 2021 Meta ULC. All rights reserved