The dilemma of the prolonged QT interval in early drug studies

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

The dilemma of the prolonged QT interval in early drug studies

Abstract

References

Electrocardiographic changes and cardiac arrhythmias in patients receiving psychotropic drugs

Iatrogenic 'torsade de pointes' ventricular tachycardia

Precordial QT interval dispersion as a marker of torsade de pointes. Disparate effects of class Ia antiarrhythmic drugs and amiodarone

Cardiotoxic effects of astemizole overdose in children

Torsades de pointes complicating treatment with terfenadine

QT interval prolongation predicts cardiovascular mortality in an apparently healthy population

Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma.

Variability of the QT measurement in healthy men, with implications for selection of an abnormal QT value to predict drug toxicity and proarrhythmia

QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest

Acute electrophysiologic effects of an HT2-serotonin antagonist, ketanserin, in humans

Electrocardiographic changes induced by inhaled salbutamol after treatment with bendrofluazide: effects of replacement therapy with potassium, magnesium and triamterene

Effects of bepridil and diltiazem on ventricular repolarization in angina pectoris

Association of intravenous erythromycin and potentially fatal ventricular tachycardia with Q-T prolongation (torsades de pointes)

The long QT syndromes: a critical review, new clinical observations and a unifying hypothesis

Evaluation of 10 QT prediction formulas in 881 middle-aged men from the seven countries study: emphasis on the cubic root Fridericia's equation

ECG changes during haloperidol and pimozide treatment of Tourette's disorder

Incidence and clinical features of the quinidine-associated long QT syndrome: implications for patient care

Polymorphous ventricular tachycardia: clinical characterization, therapy, and the QT interval

Local anaesthetic and anti-arrhythmic actions of alprenolol relative to its effect on intracellular potentials and other properties of isolated cardiac muscle

Electrophysiologic precursors of ventricular tachyarrhythmias

Long QT: good, bad or indifferent?

An exponential formula for heart rate dependence of QT interval during exercise and cardiac pacing in humans: reevaluation of Bazett's formula

Side effects of non-steroidal anti-inflammatory drugs

Procainamide-induced polymorphous ventricular tachycardia

Etiology, warning signs and therapy of torsade de pointes. A study of 10 patients

Drug-induced torsade de pointes. Incidence, management and prevention

Hypertrophy, conduction velocity, and ventricular arrhythmias

Mechanisms of cardiac arrhythmias

Torsades de pointes and proarrhythmia

Cardiac effect of halofantrine

Measurement of the QT interval and the risk associated with QTc interval prolongation: a review

Is QT interval prolongation harmful? A regulatory perspective

Clinical relevance of cardiac arrhythmias generated by afterdepolarizations. Role of M cells in the generation of U waves, triggered activity and torsade de pointes

Antiarrhythmic drugs and torsade de pointes

Evidence for the presence of fatty acid binding protein in avian granulosa cells

Difference in QT interval measurement on ambulatory ECG compared with standard ECG

Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval and sudden death

The P wave, P-R interval, and Q-T ratio of the normal orthogonal electrocardiogram

The measurement of the Q-T interval of the electrocardiogram

Citations

Usefulness, usability, and quality criteria for noninvasive methods in cardiovascular clinical pharmacology

Methodological considerations in the design of trials for safety assessment of new drugs and chemical entities

Pharmacokinetic-pharmacodynamic modeling in the data analysis and interpretation of drug-induced QT/QTc prolongation

A review of class III antiarrhythmic agents for atrial fibrillation: maintenance of normal sinus rhythm

Adverse drug reactions in patients with cardiovascular disease

ILSI-HESI cardiovascular safety subcommittee dataset: an analysis of the statistical properties of QT interval and rate-corrected QT interval (QTc)

Lenalidomide at therapeutic and supratherapeutic doses does not prolong QTc intervals in the thorough QTc study conducted in healthy men

Percentile categorization of QT interval as an approach for identifying adult patients at risk for cardiovascular death

Comparative study of mortality rates and cardiac dysrhythmias in post-marketing surveillance studies of sertindole and two other atypical antipsychotic drugs, risperidone and olanzapine

The influence of cisapride and clarithromycin on QT intervals in healthy volunteers

QTc prolongation with antipsychotics: is routine ECG monitoring recommended?

Rules of evidence for cancer molecular-marker discovery and validation

Potentially significant drug interactions of class III antiarrhythmic drugs

Behavioral studies of female sex workers in China: a literature review and recommendation for future research

Psychotropic drugs, cardiac arrhythmia, and sudden death

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