The Dimension of Time in Host-Microbiome Interactions

MSystems
Giulia T UhrChristoph A Thaiss

Abstract

The intestinal microbiota contains trillions of commensal microorganisms that shape multiple aspects of host physiology and disease. In contrast to the host's genome, the microbiome is amenable to change over the course of an organism's lifetime, providing an opportunity to therapeutically modulate the microbiome's impact on human pathophysiology. In this Perspective, we highlight environmental factors that regulate the temporal dynamics of the intestinal microbiome, with a particular focus on the different time scales at which they act. We propose that the identification of transient and intermediate states of microbiome responses to perturbations is essential for understanding the rules that govern the behavior of this ecosystem. The delineation of microbiome dynamics is also helpful for distinguishing cause and effect in microbiome responses to environmental stimuli. Understanding the dimension of time in host-microbiome interactions is therefore critical for therapeutic strategies that aim at short-term or long-term engineering of the intestinal microbial community.

References

Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Maria G Dominguez-BelloRob Knight
Sep 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Les Dethlefsen, David A Relman
Jun 1, 2011·Genome Biology·J Gregory CaporasoRob Knight
Sep 3, 2011·Science·Gary D WuJames D Lewis
Feb 3, 2012·Nature·Jorge Henao-MejiaRichard A Flavell
Jul 17, 2012·Nature·Marcus J ClaessonPaul W O'Toole
Nov 16, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hannah V CareyRob Knight
Jul 6, 2013·Science·Jeremiah J FaithJeffrey I Gordon
Dec 18, 2013·Nature·Lawrence A DavidPeter J Turnbaugh
Mar 4, 2014·FEBS Letters·Georg K Gerber
Aug 26, 2014·Genome Biology·Lawrence A DavidEric J Alm
Nov 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Andrew H MoellerHoward Ochman
Nov 21, 2014·Science Translational Medicine·Viorica BranisteSven Pettersson
Dec 4, 2014·Cell Metabolism·Amir ZarrinparSatchidananda Panda
Dec 24, 2014·Cell Host & Microbe·Rachel N CarmodyPeter J Turnbaugh
Apr 9, 2015·Journal of the American Geriatrics Society·Heidi J Zapata, Vincent J Quagliarello
May 21, 2015·MBio·Lawrence A DavidPeter J Turnbaugh
Aug 5, 2015·Proceedings of the National Academy of Sciences of the United States of America·Xue LiangGarret A FitzGerald
Oct 9, 2015·PLoS Pathogens·Christoph A ThaissEran Elinav
Jan 15, 2016·Nature·Erica D SonnenburgJustin L Sonnenburg
Jan 20, 2016·Science·Paul W O'Toole, Ian B Jeffery
Jun 17, 2016·Science Translational Medicine·Nicholas A BokulichMartin J Blaser
Jul 8, 2016·Nature·Christoph A ThaissEran Elinav
Jul 28, 2016·Science·Andrew H MoellerHoward Ochman
Jul 31, 2016·Genes & Development·Maayan LevyEran Elinav
Oct 7, 2016·Nature Medicine·Bjoern O Schroeder, Fredrik Bäckhed
Oct 21, 2016·Clinical & Translational Immunology·Angélica Thomaz VieiraCaroline Marcantonio Ferreira
Nov 8, 2016·Nature Biotechnology·Christopher T BrownJillian F Banfield
Dec 3, 2016·Cell·Christoph A ThaissEran Elinav
Feb 22, 2017·PLoS Computational Biology·Sean M GibbonsEric J Alm
Mar 25, 2017·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Lena TakayasuMasahira Hattori
Aug 12, 2017·Cell Host & Microbe·Paola TogniniPaolo Sassone-Corsi
Aug 26, 2017·Science·Samuel A SmitsJustin L Sonnenburg
Oct 14, 2017·Science Advances·Keith A MartinezMaria G Dominguez-Bello

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Citations

Jun 6, 2019·MSystems·Kirti Nath, Christoph A Thaiss
May 30, 2020·Proceedings of the National Academy of Sciences of the United States of America·Simon van Vliet, Michael Doebeli
Mar 21, 2020·Frontiers in Psychology·Javier Suárez, Vanessa Triviño
Nov 27, 2019·Nutrients·Emily R LeemingCaroline I Le Roy
Feb 13, 2020·The American Journal of Clinical Nutrition·M Isabel OrdizMark J Manary
Jul 16, 2020·Microorganisms·Veronica MoskoviczBoaz Mizrahi
Jun 16, 2019·EBioMedicine·Hélène C DescampsChristoph A Thaiss
Apr 16, 2020·Endocrinology·Yelina AlvarezChristoph A Thaiss
Oct 23, 2020·Indian Journal of Microbiology·Natalia NaumovaMarsel Kabilov
Apr 15, 2020·Microbial Pathogenesis·Ava BehrouziSeyed Davar Siadat
May 1, 2021·Animals : an Open Access Journal From MDPI·Gerald C ShursonPedro E Urriola
Aug 28, 2021·Nature Communications·Lucas P HenryJulien F Ayroles

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