The dimeric and tetrameric octarepeat fragments of prion protein behave differently to its monomeric unit

Dalton Transactions : an International Journal of Inorganic Chemistry
Daniela ValensinHenryk Kozlowski

Abstract

Potentiometric and spectroscopic data have shown that octarepeat dimer and tetramer are much more effective ligands for Cu(II) ions than simple octapeptide. Thus, the whole N-terminal segment of prion protein due to cooperative effects, could be more effective in binding of Cu(II) than simple peptides containing a His residue. The gain of the Cu(II) binding by longer octarepeat peptides derives from the involvement of up to four imidazoles in the coordination of the first Cu(II) ion. This type of binding increases the order of the peptide structure, which allows successive metal ions for easier coordination.

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Citations

Jun 1, 2005·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Diego La MendolaValeria Zito
Sep 8, 2005·Journal of the American Chemical Society·Madhuri ChattopadhyayGlenn L Millhauser
Jun 29, 2005·Chemical Communications : Chem Comm·Paweł StańczakHenryk Kozłowski
Nov 2, 2006·Annual Review of Physical Chemistry·Glenn L Millhauser
Aug 2, 2011·Chemical & Pharmaceutical Bulletin·Aya KojimaToshifumi Akizawa
Apr 17, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Caterina MiglioriniDaniela Valensin
May 27, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Christelle HureauPierre Dorlet
Dec 3, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Francesco GuerrieriGiovanni La Penna
Jul 9, 2009·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Norifumi Yamamoto, Kazuo Kuwata
Jul 14, 2004·Dalton Transactions : an International Journal of Inorganic Chemistry·Pawel StańczakHenryk Kozłowski
Jun 25, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Aleksandra HecelHenryk Kozlowski
Jul 17, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Raffaele P BonomoLaura I Vagliasindi
Sep 20, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Snezana RajkovićImre Sóvágó
Mar 26, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Raffaele P BonomoLaura I Vagliasindi
Apr 15, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Teresa Kowalik-JankowskaMariola Kuczer
Apr 23, 2010·Chemistry : a European Journal·Diego La MendolaEnrico Rizzarelli
Apr 28, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Henryk KozlowskiMaurizio Remelli
Oct 4, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Csilla KállayImre Sóvágó
Aug 10, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Imre Sóvágó, Katalin Osz
Jul 11, 2006·The Biochemical Journal·Mark A WellsJonathan P Waltho
Nov 22, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Antonio MagrìDiego La Mendola
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Oct 1, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Fabio PontecchianiHenryk Kozlowski
Aug 25, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Aleksandra KotyniaJustyna Brasuń
Aug 15, 2018·International Journal of Molecular Sciences·Antonio Magrì, Diego La Mendola
May 31, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Slawomir PotockiHenryk Kozlowski
Mar 28, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Raffaele P BonomoLaura I Vagliasindi
Aug 13, 2008·Journal of the American Chemical Society·Andrés BinolfiClaudio O Fernández
Jul 27, 2012·Journal of Inorganic Biochemistry·Ariel A Valiente-GabioudClaudio O Fernández
Feb 12, 2008·Journal of Inorganic Biochemistry·Kinga KulonHenryk Kozłowski
Sep 30, 2009·Journal of Inorganic Biochemistry·Attila JancsóTamás Gajda
Dec 20, 2011·Journal of Inorganic Biochemistry·Danuta WitkowskaHenryk Kozlowski

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