The dipsogenic effect of intracerebroventricular infusion of hypertonic NaCl in the sheep is mediated mainly by the Na ion

Acta Physiologica Scandinavica
M RundgrenR S Weisinger

Abstract

In order to examine the importance of the chloride ion in the dipsogenic effect of intracerebroventricular (ICV) infusion of hypertonic NaCl, the water intake in response to 30-min ICV infusions of hypertonic solutions of different Na salts (0.25 M NaCl, NaI, NaSCN and 0.125 M Na2S2O3), mannitol (0.5 M) and choline chloride (0.25 M) was studied in the sheep. All solutions of the Na salts caused significant water drinking compared with ICV control infusions of isotonic artificial cerebrospinal fluid (CSF), except Na thiosulphate (Na2S2O3), which was much less effective, even after equilibration of its osmolality with the other sodium solutions by adding mannitol (0.125 M Na2S2O3/0.25 M mannitol). An inconsistent and small intake of water was induced by ICV hypertonic mannitol and choline chloride. It is concluded that the dipsogenic effect of ICV infusion of hypertonic NaCl in the sheep is mainly caused by the increased Na rather than the Cl ion concentration or the hyperosmolality in the extracellular fluid of juxtaventricular brain tissue.

References

Jul 1, 1978·Physiological Reviews·B Andersson
Feb 3, 1978·Brain Research·M J McKinleyR S Weisinger
Sep 1, 1967·Acta Physiologica Scandinavica·B AnderssonR G Warner
May 1, 1980·Neuroendocrinology·S HatzikostasR S Weisinger

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Citations

Oct 1, 1992·Physiology & Behavior·M P Rosas-ArellanoL P Solano-Flores
Apr 1, 1992·Clinical and Experimental Pharmacology & Physiology·Y KawanoM Kuramochi
Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·J Shah, B S Jandhyala
Jan 28, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hiromi Tsushima, Mayumi Mori

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