The direct and sustained consequences of severe placental hypoxia on vascular contractility

PloS One
Philippe VangriekenPaul M H Schiffers

Abstract

Preeclampsia is a major health problem in human pregnancy, severely complicating 5-8% of all pregnancies. The emerging molecular mechanism is that conditions like hypoxic stress trigger the release of placental messengers into the maternal circulation, which causes preeclampsia. Our objective was to develop an in vitro model, which can be used to further elucidate the molecular mechanisms of preeclampsia and which might be used to find a remedy. Human non-complicated term placentas were collected. Placental explants were subjected to severe hypoxia and the conditioned media were added to chorionic arteries that were mounted into a myograph. Contractile responses of the conditioned media were determined, as well as effects on thromboxane-A2 (U46619) induced contractility. To identify the vasoactive compounds present in the conditioned media, specific receptor antagonists were evaluated. Factors released by placental explants generated under severe hypoxia induced an increased vasoconstriction and vascular contractility to thromboxane-A2. It was found that agonists for the angiotensin-I and endothelin-1 receptor released by placental tissue under severe hypoxia provoke vasoconstriction. The dietary antioxidant quercetin could par...Continue Reading

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Citations

Aug 1, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Philippe VangriekenPaul M H Schiffers
Jan 13, 2021·PloS One·Philippe VangriekenAlex H V Remels
Feb 2, 2021·Reproductive Sciences·Philippe VangriekenAlex H V Remels

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