The Discover artificial disc replacement versus fusion in cervical radiculopathy--a randomized controlled outcome trial with 2-year follow-up

The Spine Journal : Official Journal of the North American Spine Society
Martin SkeppholmClaes Olerud

Abstract

Several previous studies comparing artificial disc replacement (ADR) and fusion have been conducted with cautiously positive results in favor of ADR. This study is not, in contrast to most previous studies, an investigational device exemption study required by the Food and Drug Administration for approval to market the product in the United States. This study was partially funded with unrestricted institutional research grants by the company marketing the artificial disc used in this study. To compare outcomes between the concepts of an artificial disc to treatment with anterior cervical decompression and fusion (ACDF) and to register complications associated to the two treatments during a follow-up time of 2 years. This is a randomized controlled multicenter trial, including three spine centers in Sweden. The study included patients seeking care for cervical radiculopathy who fulfilled inclusion criteria. In total, 153 patients were included. Self-assessment with Neck Disability Index (NDI) as a primary outcome variable and EQ-5D and visual analog scale as secondary outcome variables. Patients were randomly allocated to either treatment with the Depuy Discover artificial disc or fusion with iliac crest bone graft and plating. ...Continue Reading

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Citations

Oct 31, 2015·The Spine Journal : Official Journal of the North American Spine Society·Michael F ShriverThomas E Mroz
Feb 3, 2016·Clinical Orthopaedics and Related Research·Zhao-Ming ZhongJian-Ting Chen
Mar 27, 2016·The Spine Journal : Official Journal of the North American Spine Society·Martin SkeppholmClaes Olerud
Jul 15, 2015·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jian KangRui Gao
Jun 18, 2016·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Shihua ZouHui Meng
Jan 13, 2018·Neurosurgery·Pierce D NunleyMarcus B Stone
Dec 16, 2017·Journal of Neurosurgery. Spine·Anna MacDowallClaes Olerud
Jul 19, 2018·Spine·Christoph MehrenKarin Wuertz-Kozak
Feb 15, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Xuan CaiXijing He
Nov 2, 2019·Asian Spine Journal·Catarina MarquesClaes Olerud
Mar 16, 2017·Journal of Neurosurgery. Spine·Peng-Yuan ChangHenrich Cheng
Jul 19, 2017·Upsala Journal of Medical Sciences·Anna MacDowallClaes Olerud
Jul 6, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Christoph MehrenH Michael Mayer
Dec 25, 2016·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jarle SundsethUNKNOWN NORCAT study group
May 12, 2017·Current Reviews in Musculoskeletal Medicine·Dante LevenSheeraz Qureshi
May 16, 2017·Upsala Journal of Medical Sciences·Anna MacDowallClaes Olerud
Apr 18, 2018·Global Spine Journal·Jordan C XuThomas E Mroz
Aug 1, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·T DufourJ P Steib
Dec 7, 2018·International Orthopaedics·Melvin C MakhniKiehyun Daniel Riew
Jul 15, 2020·BMC Musculoskeletal Disorders·Ting-Kui WuBei-Yu Wang
Mar 28, 2020·Asian Spine Journal·Nickul Saral JainJeffrey Chun Wang
Jan 21, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Catarina MarquesClaes Olerud
Aug 6, 2021·JAMA Network Open·Tonje Okkenhaug JohansenØystein Petter Nygaard
Dec 17, 2021·Yonsei Medical Journal·Jun Jae ShinYoon Ha

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