The discovery and characterization of a novel scaffold as a potent hepatitis C virus inhibitor

Chemical Communications : Chem Comm
Na LiuChunquan Sheng

Abstract

HCV infections are a major global health concern. Although direct acting antiviral agents have significantly improved the response rate of anti-HCV therapy, they also suffer from drug resistance, unfavorable pharmacokinetic profiles and high costs. Thus, it is still highly desirable to develop new anti-HCV therapeutics. Herein a novel anti-HCV benzothiazole scaffold was discovered by phenotypic screening. Further target characterization and structural optimization studies revealed that the benzothiazole-disulfoamide derivatives were potent anti-HCV molecules with good selectivity and acted by targeting NS5A.

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Citations

Oct 16, 2016·Chemistry : a European Journal·Edoardo TortiMaurizio Fagnoni
Jul 25, 2020·The Journal of Pharmacy and Pharmacology·Yahya I AsiriMohd Z Hassan
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Larisa V ZhilitskayaNina O Yarosh
May 18, 2021·Chemistry of Heterocyclic Compounds·Larisa V Zhilitskaya, Nina О Yarosh

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