PMID: 18407207Jul 1, 1994Paper

The discovery of 9-cis retinoic acid: a hormone that binds the retinoid-X receptor

Trends in Endocrinology and Metabolism : TEM
B F TateJ F Grippo

Abstract

Two classes of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid-X receptors (RXRs), mediate the physiologic activity of retinoids. The RXRs can form biologically active heterodimers with the RARs and with other nuclear receptors, including the vitamin-D, thyroid hormone, and peroxisome proliferator-activated receptors. Thus, the RXRs may play a pivotal role in modulating the action of other hormones or ligands. The RXRs were originally classified as orphan receptors whose cognate ligand was unknown until recently, when 9-cis retinoic acid (9-cis RA) was discovered to bind directly and activate this family of receptors. Since 9-cis RA also binds and activates the RARs, it is interesting to speculate that this natural ligand may regulate a broad range of physiologic processes by mediating transcriptional activity through both RAR- and RXR-linked pathways.

References

Mar 1, 1992·Genes & Development·D J MangelsdorfR M Evans
Sep 30, 1992·Annals of the New York Academy of Sciences·A A LevinA Lovey
Oct 1, 1992·Trends in Biochemical Sciences·M LeidP Chambon
Apr 1, 1992·Archives of Biochemistry and Biophysics·W StahlH Sies
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A KrustP Chambon
Dec 17, 1987·Nature·V GiguereR M Evans
Apr 28, 1988·Nature·N BrandA Dejean
Nov 1, 1988·Trends in Genetics : TIG·S Green, P Chambon
May 1, 1988·The British Journal of Nutrition·A Ben-AmotzM Avron
Aug 17, 1993·Biochemical Pharmacology·J C Kraft, M R Juchau
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G AllenbyP Chambon
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K L GearingJ A Gustafsson
Feb 18, 1993·Nature·C CarlbergW Hunziker
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·H KellerW Wahli
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y YangJ D Ashwell
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J J RepaM Clagett-Dame
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M E NewcomerD E Ong
Feb 1, 1993·The Journal of Nutrition·A C Ross
Feb 1, 1993·Biology of Reproduction·R S PappasD E Ong
Jul 1, 1993·Trends in Endocrinology and Metabolism : TEM·X K Zhang, M Kahl

❮ Previous
Next ❯

Citations

Jan 1, 1996·Journal of Cellular Biochemistry. Supplement
May 1, 1997·Pediatric Research·T N George, J M Snyder
Aug 14, 2001·São Paulo Medical Journal = Revista Paulista De Medicina·R D CançadoR de C Alves
Oct 12, 2010·Immunopharmacology and Immunotoxicology· SiddikuzzamanV M Berlin Grace
Nov 8, 2001·Journal of Enzyme Inhibition·G TaibiC M Nicotra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.