The discovery of Arylex™ active and Rinskor™ active: Two novel auxin herbicides

Bioorganic & Medicinal Chemistry
Jeffrey B EppCarla N Yerkes

Abstract

Multiple classes of commercially important auxin herbicides have been discovered since the 1940s including the aryloxyacetates (2,4-D, MCPA, dichlorprop, mecoprop, triclopyr, and fluroxypyr), the benzoates (dicamba), the quinoline-2-carboxylates (quinclorac and quinmerac), the pyrimidine-4-carboxylates (aminocyclopyrachlor), and the pyridine-2-carboxylates (picloram, clopyralid, and aminopyralid). In the last 10 years, two novel pyridine-2-carboxylate (or picolinate) herbicides were discovered at Dow AgroSciences. This paper will describe the structure activity relationship study that led to the discovery of the 6-aryl-picolinate herbicides Arylex™ active (2005) and Rinskor™ active (2010). While Arylex was developed primarily for use in cereal crops and Rinskor is still in development primarily for use in rice crops, both herbicides will also be utilized in additional crops.

References

Mar 23, 2011·Plant Science : an International Journal of Experimental Plant Biology·Sibu Simon, Jan Petrášek
Apr 3, 2012·Nature Chemical Biology·Luz Irina A Calderón VillalobosMark Estelle

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Citations

Apr 19, 2016·Journal of Agricultural and Food Chemistry·Chi-Linh Do-ThanhMichael D Best
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Oct 22, 2016·Pest Management Science·Ann M BuysseXinpei Huang
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