The discovery of BMAA, and examples of biomagnification and protein incorporation involving other non-protein amino acids

Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
E Arthur Bell

Abstract

Because of the similarity of ALS/PDC symptoms to those of the paralytic disease lathyrism, cycad seeds from Guam were analyzed for the presence of the non-protein amino acid b-ODAP, which is known to cause lathyrism. Although b-ODAP was not detected, a novel non-protein amino acid, now known as BMAA, was isolated. Primates are more sensitive to BMAA than rodents. It is possible that BMAA when ingested at a low concentration over a long period might be responsible for ALS/PDC. Some non-protein amino acids, including domoic acid and indospicine, are known to be biomagnified. Other non-protein amino acids including azetidine-2-carboxylic acid, canavanine, and selenium containing analogues of cystine and methionine have been shown to be misincorporated into proteins. Perhaps BMAA will not be the only non-protein amino acid that will be found in the brain tissues of those who died of a neurological disease.

References

Nov 1, 1988·Australian Veterinary Journal·M P HegartyR Cameron
Feb 1, 1968·The Biochemical Journal·R M O'NealR E Koeppe
May 2, 2003·Journal of Agricultural and Food Chemistry·E Arthur Bell
Aug 13, 2003·Neurology·Sandra Anne Banack, Paul Alan Cox
Oct 1, 1954·Archives of Biochemistry and Biophysics·G F McKAYF M STRONG
Oct 1, 1962·The Biochemical Journal·E A BELL
Aug 1, 1962·The Journal of Experimental Medicine·C I LEVENE
Aug 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Susan J MurchSandra Anne Banack
Sep 10, 2004·Acta Neurologica Scandinavica·S J MurchO W Sacks

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Citations

Jan 18, 2006·Journal of Epidemiology and Community Health·E G Knox
Mar 3, 2012·Environmental Health Perspectives·Wendee Holtcamp
Jul 28, 2013·International Journal of Molecular Sciences·Francesca TrojsiGioacchino Tedeschi
Mar 21, 2015·Marine Drugs·Natalia Jakubowska, Elżbieta Szeląg-Wasielewska
Jan 23, 2016·Proceedings. Biological Sciences·Paul Alan CoxSandra Anne Banack
Jul 13, 2011·Medical Hypotheses·Nicholas C FieldElijah W Stommel
Dec 19, 2012·Medical Hypotheses·Elijah W StommelTracie A Caller
Jan 18, 2011·Neurobiology of Aging·Moonhee Lee, Patrick L McGeer
Apr 24, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kiyo MondoDeborah C Mash
Aug 30, 2011·Toxicon : Official Journal of the International Society on Toxinology·Mafalda S BaptistaVitor M Vasconcelos
Jan 5, 2013·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Walter G BradleyPaul Alan Cox
Apr 24, 2015·Environmental Science and Pollution Research International·Mafalda S BaptistaVitor M Vasconcelos
Aug 25, 2017·Proteomics·Joshua BeriMichael S Bereman
May 26, 2017·Neurotoxicity Research·Paul Alan CoxGilles J Guillemin
Nov 17, 2020·Neurotoxicity Research·Paul Alan Cox

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