The discovery of RFI-641 as a potent and selective inhibitor of the respiratory syncytial virus

Bioorganic & Medicinal Chemistry Letters
Antonia A NikitenkoT Z Wang

Abstract

The design and synthesis of a new potent and selective inhibitor of the respiratory syncytial virus are described. This compound, RFI-641, emerged from analysis of the structure-activity relationship in a series of biphenyl triazine anionic compounds possessing specific anti-RSV activity. The key synthetic step involves coupling of diaminobiphenyl 11 with two equivalents of chlorotriazine 10 under microwave conditions. RFI-641 inhibited RSV in vitro and in vivo models.

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Citations

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Dec 16, 2020·ACS Biomaterials Science & Engineering·Juhi ChakrabortySourabh Ghosh

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