PMID: 6160221Jan 1, 1980Paper

The discrimination between different blood-CSF barrier dysfunctions and inflammatory reactions of the CNS by a recent evaluation graph for the protein profile of cerebrospinal fluid

Journal of Neurology
Hansotto Reiber

Abstract

A graph for the evaluation of the CSF-protein profile is presented as a basic program for the clinical-neurochemical laboratory. The graph has the following advantages: Simultaneous information on the functional state of the blood-CSF barrier and the inflammatory response of the CNS; maximal sensitivity for the determination of a pathological local IgG production in CNS--with the possibility of calculating the IgG fraction in CSF originating from the CNS; minimal number of protein assays necessary (albumin and IgG in serum and CSF); suitable for the demonstration of the course of the disease in a single patient as well as for demonstration of a group of cases for statistical purposes. Complementary chemical investigations and the correspondence with the clinical diagnosis are discussed for a number of typical cases. Two different types of blood-CSF barrier dysfunctions are discriminated by a proportional and a dis-proportionate increase of the CSF/serum protein concentration gradients.

References

May 18, 1978·Journal of Neurology·G Schliep, K Felgenhauer
Apr 13, 1979·Deutsche medizinische Wochenschrift·T O KleineW Bablok
Mar 13, 1978·European Journal of Pediatrics·A Kohlschütter
Dec 15, 1974·Klinische Wochenschrift·K Felgenhauer
Mar 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·B Delpech, E Lichtblau
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Jan 1, 1980·Journal of Neurology·D Klingler, S Necek
Aug 8, 2009·Der Nervenarzt·S SchwarzB Storch-Hagenlocher

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Citations

Jan 1, 1984·Journal of Neurology·A LeonardiM Vische
Jan 1, 1988·Journal of Neurology·R BiniekK Balzer
Dec 1, 1990·Journal of Neurology·J HellerK Schimrigk
Feb 1, 1990·Journal of Neurology·R MartinH G Mertens
Jan 1, 1988·Acta neurochirurgica·T WetterlingM Nekic
Feb 1, 1990·Italian Journal of Neurological Sciences·S RolandoA Leonardi
May 1, 1996·Molecular and Chemical Neuropathology·A Dorta-Contreras, R Silva-Somoza
Mar 19, 2005·European Journal of Clinical Pharmacology·Anargyros XenocostasHans A Messner
May 15, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·H ReiberK Felgenhauer
Mar 30, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·H Reiber, K Felgenhauer
Jun 1, 1984·Journal of the Neurological Sciences·H I Schipper, H W Prange
Oct 1, 1986·Journal of the Neurological Sciences·G Keir, E J Thompson
Feb 1, 1987·Journal of the Neurological Sciences·K Felgenhauer, H J Schädlich
Oct 1, 1991·Journal of the Neurological Sciences·M Trbojevic-CepeI Pavlicek
Dec 1, 1988·Journal of Neuroimmunology·R BiniekH J Lehmann
Aug 18, 1987·Neuroscience Letters·J KornhuberM E Kornhuber
Mar 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·S Schwarz, P Pohl
Mar 10, 2001·Journal of the Neurological Sciences·H Reiber, J B Peter
Apr 30, 1998·Journal of the Neurological Sciences·M Trbojević-CepeN Stambuk
Jul 18, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·S BisserM O Jauberteau
Nov 30, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Gabriele HeineHartmut Selle
Jul 20, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S Lotric-FurlanF Strle
Nov 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·E SchmutzhardP Pohl

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