PMID: 240661Jul 1, 1975Paper

The disposition of ftorafur in rats after intravenous administration

Drug Metabolism and Disposition : the Biological Fate of Chemicals
A M Cohen

Abstract

The excretion, distribution, and metabolism of ftorafur was studied in rats following a single intravenous injection of radioactively labeled drug. Approximately 55% of the administered radioactivity was excreted as 14CO2, while 23% was eliminated via the urinary route in 24 hr. Less than 2% was excreted in the feces. The major excretory product found in the urine was unmetabolized ftorafur. However, the proportions of radioactively labeled metabolites such as 5-fluorouracil and urea increased with time after injection. The half-life of ftorafur in plasma was estimated to be approximately 5 hr. The drug was fairly evenly distributed to liver, small intestine, spleen, kidney, and brain. Highest initial concentrations were found in the liver, which also retained more drug for a longer period than the other tissues. The liver was also found to contain the highest initial proportions of 5-fluorouracil and its metabolites. The results obtained are consistent with the suggestion that ftorafur may be a depot form of 5-fluorouracil and that the liver may be the primary site at which the latter drug is released in vivo.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

Related Papers

Drug Metabolism and Disposition : the Biological Fate of Chemicals
B N SwansonM B Sporn
Drug Metabolism and Disposition : the Biological Fate of Chemicals
J J DilibertoL S Birnbaum
Drug Metabolism and Disposition : the Biological Fate of Chemicals
M J McNulty, H D Heck
© 2021 Meta ULC. All rights reserved