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The dissipation of neuropathic pain paradoxically involves the presence of tumor necrosis factor-alpha (TNF)

Neuropharmacology

Mar 1, 2005

Tracey A IgnatowskiRobert Nicholas Spengler

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Abstract

Neuropathic pain, a chronic disabling pain arising from nerve injury, develops a central component. In brain neurons, tumor necrosis factor-alpha (TNF) levels intensify and TNF-inhibition of norepinephrine (NE) release, dependent upon alpha(2)-adrenergic activation, amplifies during neu...read more

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Adrenergic Agents
Adrenergic Agonists
Amines
Amitriptyline
Analgesics
Antidepressive Agents
Brain
Cell Nucleus
Clonidine
Dactinomycin
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The dissipation of neuropathic pain paradoxically involves the presence of tumor necrosis factor-alpha (TNF)

Neuropharmacology

Mar 1, 2005

Tracey A IgnatowskiRobert Nicholas Spengler

PMID: 15721177

DOI: 10.1016/j.neuropharm.2004.11.001

Abstract

Neuropathic pain, a chronic disabling pain arising from nerve injury, develops a central component. In brain neurons, tumor necrosis factor-alpha (TNF) levels intensify and TNF-inhibition of norepinephrine (NE) release, dependent upon alpha(2)-adrenergic activation, amplifies during neu...read more

Mentioned in this Paper

Adrenergic Agents
Adrenergic Agonists
Amines
Amitriptyline
Analgesics

Similar Papers Found In These Feeds

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Paper Details
References
  • References
  • Citations17
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations17
12

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