The Dissociative Subtype of Posttraumatic Stress Disorder: Unique Resting-State Functional Connectivity of Basolateral and Centromedial Amygdala Complexes

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Andrew A NicholsonRuth A Lanius

Abstract

Previous studies point towards differential connectivity patterns among basolateral (BLA) and centromedial (CMA) amygdala regions in patients with posttraumatic stress disorder (PTSD) as compared with controls. Here we describe the first study to compare directly connectivity patterns of the BLA and CMA complexes between PTSD patients with and without the dissociative subtype (PTSD+DS and PTSD-DS, respectively). Amygdala connectivity to regulatory prefrontal regions and parietal regions involved in consciousness and proprioception were expected to differ between these two groups based on differential limbic regulation and behavioral symptoms. PTSD patients (n=49) with (n=13) and without (n=36) the dissociative subtype and age-matched healthy controls (n=40) underwent resting-state fMRI. Bilateral BLA and CMA connectivity patterns were compared using a seed-based approach via SPM Anatomy Toolbox. Among patients with PTSD, the PTSD+DS group exhibited greater amygdala functional connectivity to prefrontal regions involved in emotion regulation (bilateral BLA and left CMA to the middle frontal gyrus and bilateral CMA to the medial frontal gyrus) as compared with the PTSD-DS group. In addition, the PTSD+DS group showed greater amygd...Continue Reading

References

Jan 1, 1995·Journal of Traumatic Stress·D D BlakeT M Keane
Dec 23, 1998·Biological Psychiatry·J LeDoux
Mar 5, 2003·Child Abuse & Neglect·David P BernsteinWilliam Zule
Mar 13, 2003·Cerebral Cortex·T WolbersC Büchel
Mar 20, 2003·Biological Psychiatry·Johanne LévesqueMario Beauregard
Sep 15, 2004·Neuron·Elizabeth A PhelpsJoseph E LeDoux
Nov 11, 2005·Journal of Traumatic Stress·John BriereMarsha Runtz
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
Nov 7, 2006·Psychiatry Research·Nicholas MedfordMary L Phillips
Nov 6, 2008·Social Cognitive and Affective Neuroscience·Sarah J BanksK Luan Phan
Dec 27, 2008·NeuroImage·Amy Krain RoyMichael P Milham
May 23, 2009·NeuroImage·Rasmus M BirnPeter A Bandettini
Jul 25, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lisa M Shin, Israel Liberzon
Dec 26, 2009·Social Cognitive and Affective Neuroscience·Matthew D Lieberman, William A Cunningham
Mar 17, 2010·The American Journal of Psychiatry·Tanja Jovanovic, Kerry J Ressler
Apr 3, 2010·The American Journal of Psychiatry·Ruth A LaniusDavid Spiegel
Oct 23, 2010·Journal of Psychiatry & Neuroscience : JPN·Marla J S MickleboroughRuth A Lanius
Dec 21, 2010·Trends in Cognitive Sciences·Amit EtkinRaffael Kalisch
Feb 9, 2012·Journal of Psychiatry & Neuroscience : JPN·Rebecca K SripadaIsrael Liberzon
Oct 13, 2012·Biological Psychiatry·Dan J SteinRonald C Kessler
Jul 6, 2013·Journal of Psychiatric Research·Jennifer S StevensKerry J Ressler
Jul 23, 2013·Brain : a Journal of Neurology·Robert Leech, David J Sharp
Aug 10, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vanessa M BrownRajendra A Morey
Jun 9, 2014·Neuron·Sevil Duvarci, Denis Pare
Nov 25, 2014·Clinical Psychological Science : a Journal of the Association for Psychological Science·Naomi SadehWendy Heller

❮ Previous
Next ❯

Citations

Jan 1, 2015·Nature Reviews. Disease Primers·Rachel YehudaSteven E Hyman
May 15, 2015·Journal of Psychiatric Research·Jack TsaiRobert H Pietrzak
Jul 23, 2016·Cognitive, Affective & Behavioral Neuroscience·Jamie FerriTurhan Canli
Dec 22, 2016·Social Cognitive and Affective Neuroscience·Paula NeumeisterThomas Straube
May 21, 2017·European Archives of Psychiatry and Clinical Neuroscience·Annegret Krause-UtzBernet M Elzinga
Mar 23, 2018·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·Paul F Dell
Jul 29, 2018·Nature Reviews. Neuroscience·Robert J FensterJunghyup Suh
Mar 27, 2018·Current Behavioral Neuroscience Reports·Annegret Krause-Utz, Bernet Elzinga
Jun 27, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Annmarie MacNamaraK Luan Phan
May 17, 2018·BMC Psychiatry·Bailee L MalivoireCandice M Monson
Sep 26, 2020·The American Journal of Psychiatry·Lauren A M LeboisMilissa L Kaufman
Feb 1, 2017·Current Psychiatry Reports·Annegret Krause-UtzBernet M Elzinga
Sep 3, 2019·Frontiers in Neurology·Petr SojkaJ Fialová
May 3, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Robin BladesTaylor Kuhn
Aug 22, 2017·Current Psychiatry Reports·Ryan J Herringa
Jul 18, 2017·Social Psychiatry and Psychiatric Epidemiology·Stephanie RekDaniel Freeman
Sep 14, 2019·Journal of Magnetic Resonance Imaging : JMRI·Akira KunimatsuOsamu Abe
Dec 30, 2016·Brain and Behavior·Sherain HarricharanRuth A Lanius
Feb 13, 2019·Psychological Medicine·Nambeom KimSeog Ju Kim
Jul 28, 2019·Frontiers in Neuroendocrinology·Josep Moreno-Rius

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.