The distinct roles of mesenchymal stem cells in the initial and progressive stage of hepatocarcinoma

Cell Death & Disease
Chen ZongLixin Wei

Abstract

Increasing evidences suggest that mesenchymal stem cells (MSCs) could migrate to the tumor site and play a vital role in tumorigenesis and progression. However, it is still a lively debate whether MSCs exert a pro- or anticancer action. Cancer development and progression is a multistep process. Therefore, we investigated the effect of MSCs on hepatocarcinoma and whether the role of MSCs depends on the stage of cancer development. In our study, chronically exposing rats to N-diethylnitrosamine (DEN) was employed as hepatocarcinoma model. And to evaluate the effect of MSCs on hepatocarcinoma, the animals were divided into three groups: rats were injected with MSCs in the initial (DEN + MSC (Is) group) or progressive stage (DEN + MSC (Ps) group) of hepatocarcinoma, respectively. Rats injected with PBS were used as control (DEN group). Interestingly, we found that MSCs had a tumor-suppressive effect in the Is of hepatocarcinoma, yet a tumor-promotive effect in the Ps. In the Is, MSCs showed a protective role against drug damage, possibly through reducing DNA damage and ROS accumulation. Meanwhile, MSCs in the Is also exhibited anti-inflammatory and anti-liver fibrosis effect. Further, in the Ps, MSCs facilitated tumor formation not...Continue Reading

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Citations

Jun 9, 2019·The Journal of Pharmacology and Experimental Therapeutics·Shen ChengSwayam Prabha
Jun 5, 2020·Stem Cells Translational Medicine·Rhian Stavely, Kulmira Nurgali
Jul 23, 2020·Stem Cells International·Dragana MiloradovicVladislav Volarevic
Jul 8, 2020·International Journal of Molecular Sciences·Ehab Kotb ElmahallawyTokuma Yanai
Mar 3, 2019·Journal of Clinical Medicine·Stephen W Attwood, Michael J Edel
May 6, 2020·World Journal of Gastrointestinal Oncology·Jian-Nan LiKai Zhang
Jan 10, 2021·Stem Cell Reviews and Reports·Lacy E LowryJames A Bynum

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Methods Mentioned

BETA
MDA
fluorescence microscopy
PCR
flow cytometry
transgenic

Software Mentioned

Pro Plus
Image

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