The distinct structural preferences of tau protein repeat domains

Chemical Communications : Chem Comm
Xuhua LiBuyong Ma

Abstract

The tau fibrillar structures from the brain of an Alzheimer's patient have a core with a C-shaped motif of the third and fourth repeat domains (R3-R4). Our simulations indicated that the C-shaped motif is only stable for R3-R4, while R1-R2 tends to be linear in shape. These two structural motifs appear in the most stable K18 protofilament. Heparin can further stabilize the C-shaped R3-R4 motif, but not other repeats.

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Citations

May 26, 2021·Journal of Chemical Information and Modeling·Huan HeFeng Ding
Aug 21, 2020·The Journal of Physical Chemistry. B·Shruti AryaMichael T Bowers
Mar 1, 2019·The Journal of Physical Chemistry. B·Yan LuPhilippe Derreumaux
Mar 29, 2020·The Journal of Physical Chemistry. B·Philippe DerreumauxPhuong H Nguyen

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Methods Mentioned

BETA
electron microscopy

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