The distribution and function of aquaporins in the kidney: resolved and unresolved questions

Anatomical Science International
Toshiyuki MatsuzakiKuniaki Takata

Abstract

The membrane water channel aquaporin (AQP) family is composed of 13 isoforms in mammals, eight of which are reportedly expressed in the kidney: AQP1, 2, 3, 4, 6, 7, 8, and 11. These isoforms are differentially expressed along the renal tubules and collecting ducts. AQP1 and 7 are distributed in the proximal tubules, whereas AQP2, 3, and 4 occur in the collecting duct system. They play important roles in the reabsorption of water and some solutes across the plasma membrane. In contrast to other aquaporins found in the kidney, AQP6, 8, and 11 are localized to the cytoplasm rather than to the apical or basolateral membranes. It is therefore doubtful that these isoforms are directly involved in water or solute reabsorption. AQP6 is localized in acid-secreting type A intercalated cells of the collecting duct. AQP8 has been found in the proximal tubule but its cellular location has not yet been defined by immunohistochemistry. AQP11 seems to be localized in the endoplasmic reticulum (ER) of proximal tubule cells. Interestingly, polycystic kidneys develop in AQP11-null mice. Many vacuole-like structures are seen in proximal tubule cells in kidneys of newborn AQP11-null mice. Subsequently, cysts are generated, and most of the mice die ...Continue Reading

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Citations

Jun 21, 2016·International Journal of Molecular Sciences·Sayaka OshikawaMasahiro Ikeda
Feb 10, 2017·Anatomical Science International·Tatsuo Sakai
Jul 18, 2019·The American Journal of Chinese Medicine·Yalin ZhangJuan Kong
Oct 21, 2017·Reproduction in Domestic Animals = Zuchthygiene·M YesteN Prieto-Martínez
Jul 15, 2016·International Journal of Molecular Sciences·Xiao-Yan ZhangYou-Fei Guan
Dec 19, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·João C RibeiroPedro F Oliveira
Mar 16, 2021·Toxicology Reports·Miriam E MossobaRobert L Sprando
Apr 3, 2021·Frontiers in Genetics·Abul Kalam AzadParveen Afroz Chowdhury

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