PMID: 7090841Mar 1, 1982Paper

The distribution and metabolism of 14C-labelled tamoxifen in spayed female mice

Acta Pharmacologica Et Toxicologica
N WilkingN O Theve

Abstract

The distribution and metabolism of 14C-tamoxifen (a non-steroidal triaryl ethylene anti-oestrogen) have been investigated in ovarieectomized mice. The autoradiograms showed accumulation of radioactivity in the liver and the bile as an indication of an excretory pathway, but a rapid and high accumulation was also seen in the lung and the adrenals, organs normally not considered as target organs for tamoxifen. The liver and sebaceous glands could be detected on the autoradiograms up to fourteen days after a single intravenous dose. However, in most organs the amount of retained radioactivity was very low after 24 hours. By using the autoradiograms as a guideline a metabolic study was performed. High concentrations of unmetabolized tamoxifen was detected in the lung and the adrenals as well as in the pancreas. Relatively high amounts of a compound tentatively identified as 4-hydroxy-tamoxifen were present in the pancreas and the liver and there were also indications for the presence of N-desmethyl-tamoxifen in these tissues. These metabolites are considered to possess anti-oestrogenic activity.

References

Jul 1, 1979·Journal of Steroid Biochemistry·A A Sandberg, H E Rosenthal
Feb 1, 1975·Journal of Reproduction and Fertility·V C Jordan
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·B ForsgrenB Högberg
Nov 1, 1977·The Journal of Endocrinology·V C JordanG Prestwich
Jul 1, 1978·The Journal of Endocrinology·L Martin, E Middleton
Nov 1, 1973·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J M FromsonS Bramah
Sep 13, 1973·The New England Journal of Medicine·F DavidoffC Rosoff
Nov 1, 1973·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J M FromsonS Bramah
Jul 1, 1972·Metabolism: Clinical and Experimental·C J GlueckP Steiner
Aug 1, 1980·International Journal of Andrology·K Carlström, B Fredricsson
May 1, 1963·Acta Endocrinologica·S ULLBERG, G BENGTSSON

Citations

Jan 1, 1994·European Journal of Drug Metabolism and Pharmacokinetics·Y TanakaS Ninomiya
Oct 1, 1992·Neurosurgery·W ZhangY Nozawa
Apr 17, 2008·Neuropsychology Review·Jeffrey S WefelChristina A Meyers
Jul 1, 1990·The British Journal of Surgery·K E BakkevoldB Espehaug
Jun 26, 1998·Annals of Surgical Oncology·E K RobinsonE A Grimm
Mar 22, 2003·Clinical Pharmacokinetics·Karla C MorelloMichael W DeGregorio
Jan 17, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elisabeth S BergenRupert Bartsch
May 18, 2000·Cancer Treatment Reviews·E A Lien, P E Lønning

Related Concepts

Autoradiography
Castration
Zitazonium
Drug or Chemical Tissue Distribution

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Laryngeal Neoplasms

Laryngeal Neoplasms occur in the Larynx and are typically associated with smoking and alcohol consumption. Discover the latest research on Laryngeal Neoplasms here.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.