PMID: 11912061Mar 26, 2002Paper

The distribution kinetics of waterborne silver-110m in juvenile rainbow trout

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
Fernando GalvezChrister Hogstrand

Abstract

Juvenile rainbow trout (Oncorhynchus mykiss) were subjected to a 2-day radioactive pulse of 110mAg at 11.9 microg/l (as AgNO3), followed by a 19-day post-tracer exposure to non-radioactive Ag(I) (3.8 microg/l). The distribution of 110mAg in the gills, liver, intestine, kidney, brain and remaining carcass was investigated over a 19-day post-tracer period. Initially, the intestine contained the highest proportion of the 110mAg burden (34%), however, by day 8, less than 5% of the total radioactivity remained in this tissue. The majority of the 110mAg eliminated from the intestine appeared to distribute to the liver. Eventually, the 110mAg content in the liver accounted for as much as 65% of the total radioactivity in the fish. Apart from the liver and intestine, only the gills and carcass contained any appreciable amount (>5%) of the total body 110mAg content. Liver and gill samples were fractionated using differential centrifugation techniques to discern the subcellular distribution of 110mAg in these tissues. In the liver, the 110mAg levels in the cytosolic fraction increased from 35% to 72% of the total cellular burden between days 8 and 19, respectively. The radioactive pulse in the gills was predominantly found in a membrane ...Continue Reading

References

Mar 15, 1990·Toxicology and Applied Pharmacology·C Hogstrand, C Haux
Jul 1, 1974·Bulletin of Environmental Contamination and Toxicology·R L Coleman, J E Cearley
Feb 1, 1994·Toxicology Letters·F HirasawaY Takizawa
Aug 1, 1997·Comparative Biochemistry and Physiology. Part A, Physiology·J Fuentes, F B Eddy
Jul 21, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·F GalvezC M Wood

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