PMID: 3748275Jul 1, 1986Paper

The distribution of [3H]kainate binding sites in primate hippocampus is similar to the distribution of both Ca2+-sensitive and Ca2+-insensitive [3H]kainate binding sites in rat hippocampus

Neurochemical Research
D T MonaghanC W Cotman

Abstract

The distribution of [3H]kainate binding sites was determined by quantitative autoradiography in three vertebrate species: rat, monkey, and human. These animals displayed a similar pattern of binding site density in the hippocampus. Highest levels were found within the stratum lucidum and moderate levels in the inner portion of the dentate gyrus molecular layer. Although the distribution is similar, there is a lower density of binding sites in the stratum lucidum of primates than in rodents. Experiments using rat brain synaptic plasma membrane fractions indicated that inclusion of Ca2+ ions results in a selective reduction in binding at the high affinity sites. The Ca2+-inhibited and Ca2+-inhibited binding sites in the high affinity sites. The Ca2+ -inhibited and Ca2+ -insensitive binding sites in the rat hippocampus exhibited a similar distribution. Together, these results suggest that in a variety of mammalian species kainate receptors exhibit similar regional distributions, and that the high and low affinity kainate binding sites also exhibit similar regional distributions.

References

Oct 26, 1979·Brain Research·J W OlneyT de Gubareff
Dec 6, 1985·Science·J W GeddesH C Chui
Jan 1, 1981·Annual Review of Pharmacology and Toxicology·J C Watkins, R H Evans
Jan 1, 1981·Nature·A C FosterC W Cotman
Jan 21, 1983·European Journal of Pharmacology·J R Unnerstall, J K Wamsley
Jul 1, 1983·Journal of Neurochemistry·J T Coyle
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R J Walter, M W Berns

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Citations

Aug 15, 1993·European Journal of Pharmacology·T H JohansenE O Nielsen
Sep 17, 2008·Handbook of Clinical Neurology·Michalis Papadakis, Alastair Buchan
Jul 25, 2013·Journal of the International Neuropsychological Society : JINS·Shala N BlueJocelyne Bachevalier
Jun 1, 1994·Neurochemical Research·R A HallG Lynch
Dec 16, 1998·Neurobiology of Disease·G W MathernP D Adelson

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