PMID: 3756494Aug 27, 1986Paper

The distribution of adrenergic receptors in cerebral blood vessels: an autoradiographic study

Brain Research
K NakaiN Komai

Abstract

The first morphological evidence of the existence of adrenergic receptors (alpha 1, alpha 2 and beta) within the vascular walls of the central nervous system were presented using the in vitro receptor autoradiographic technique. In the rat pial arteries all three types of adrenergic receptors were demonstrated, whereas the human pial arteries failed to show significant autoradiographic grains of alpha 1 type of adrenergic receptors indicating a considerable inter-species difference in the distribution of adrenergic receptors. alpha 2 and beta receptors in human pial arteries were found not only in the arterial smooth muscle layers but also in the endothelial layers. This suggests a possibility that circulating sympathomimetic agents play some role in controlling the tone or permeability of vascular walls within the central nervous system. A distinct distribution of alpha 1 receptors in cortical layer IV where the vascular plexus was richest may suggest a relation of alpha 1 receptors and blood flow of brain parenchyma.

References

May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R SimantovS H Snyder
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleL G Sharpe
May 1, 1977·Stroke; a Journal of Cerebral Circulation·T ItakuraN Shimizu
Oct 1, 1975·The American Journal of Anatomy·M L Rennels, E Nelson
Nov 11, 1975·Stroke; a Journal of Cerebral Circulation·E P WeiJ L Patterson
Jan 1, 1970·Brain : a Journal of Neurology·E Nelson, M Rennels
May 9, 1980·Science·S J PeroutkaS H Snyder
May 1, 1981·Acta Physiologica Scandinavica·T SkärbyL Edvinsson
Apr 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·Y SakakibaraI Muramatsu
Aug 20, 1984·Brain Research·R B RothmanM A Cascieri
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·W S Young, M J Kuhar
Sep 7, 1981·Brain Research·H KobayashiM Trabucchi
Jan 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J K WamsleyM J Kuhar

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Citations

Aug 6, 1992·European Journal of Pharmacology·A L Killam, M L Cohen
Feb 29, 1988·Neuroscience Letters·J De KeyserG Vauquelin
Jun 23, 2001·Archives of Disease in Childhood. Fetal and Neonatal Edition·Z WeintraubUNKNOWN Israel Neonatal Network
Dec 19, 2012·Journal of Emergencies, Trauma, and Shock·Fabrizio Giuseppe Bonanno
Jul 20, 2011·Journal of Emergencies, Trauma, and Shock·Fabrizio Giuseppe Bonanno
Jul 20, 2011·Journal of Emergencies, Trauma, and Shock·Fabrizio Giuseppe Bonanno
Oct 27, 2020·The Journal of Pharmacology and Experimental Therapeutics·Christopher L MooreSung W Rhee
Sep 16, 2021·Journal of Neurochemistry·Yu HasegawaMotohiro Morioka

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