PMID: 9176567May 1, 1997Paper

The distribution of alpha 2 beta 1, alpha 3 beta 1 and alpha 6 beta 4 integrins identifies distinct subpopulations of basal keratinocytes in the outer root sheath of the human anagen hair follicle

Cellular and Molecular Life Sciences : CMLS
S Commo, B A Bernard

Abstract

The human hair follicle is composed of different concentric compartments, which reflect different programmes of differentiation. Using monoclonal antibodies against alpha 2 beta 1 and alpha 3 beta 1 integrins we demonstrated a shift in their expression, from a basolateral distribution in the basal cells of the lower outer root sheath, to an apicolateral expression in the upper outer root sheath, as in epidermis. This shift takes place in a transition zone, localized to the midpart of the follicle. The distinct basolateral distribution of alpha 2 beta 1 and alpha 3 beta 1 integrins in the lower portion of the outer root sheath coincides with the presence of basal cell protrusions and is probably linked to the presence of the vitreous membrane which surrounds the bottom part of the anagen human hair follicle. Moreover, we showed that the expression of alpha 6 beta 4 integrin is discontinuous along the hair follicle and coincides with that of laminin 5. Together these results establish that within a given compartment-namely the outer root sheath-several domains can be clearly identified, which probably reflect the onset of successive differentiation pathways along the hair follicle.

Citations

Sep 3, 2002·Survey of Ophthalmology·Murray A Johnstone, Daniel M Albert
May 24, 2008·International Journal of Cosmetic Science·B A Bernard
Feb 10, 2007·Head & Face Medicine·Roberto d'OvidioCaterina Foti
May 9, 2007·The Journal of Cell Biology·Katrin LorenzReinhard Fässler
Jan 29, 2000·The Journal of Investigative Dermatology·M AkiyamaH Shimizu
Mar 12, 2013·The Journal of Investigative Dermatology·Michelle Rathman-JosserandBruno A Bernard
Dec 25, 2007·Experimental Cell Research·J E KloepperR Paus
Jun 25, 2009·The British Journal of Dermatology·O Abbas, M Mahalingam
Aug 22, 2003·Experimental Dermatology·Sohaila JoubehTakashi Hashimoto
Dec 11, 2007·The British Journal of Dermatology·S MalgouriesB A Bernard
Feb 24, 2006·Experimental Cell Research·Gretel ChometonMonique Aumailley
Oct 15, 1998·Experimental Cell Research·J R Bickenbach, E Chism
Oct 13, 2016·The Journal of Investigative Dermatology·Monika PeschMonique Aumailley
Mar 8, 2017·Experimental Dermatology·Bruno A Bernard
Feb 7, 2006·Médecine sciences : M/S·Bruno A Bernard
Jun 6, 2003·Journal of the American Academy of Dermatology·Bruno A Bernard

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